intraocular — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3174	Taprenepag	CP-544326	Prostaglandin Receptor
	Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.		Prostaglandin Receptor
T12670	(Rac)-MGV354	MGV354	Others
	(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively).		Others
T0142	Brinzolamide	AL-4862	Carbonic Anhydrase
	Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.		Carbonic Anhydrase
T0106	Methazolamide	L584601,CL 8490	Carbonic Anhydrase
	Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.		Carbonic Anhydrase
T60924	Verosudil	AR-12286	ROCK
	Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ...		ROCK
T1071L	DL-Adrenaline Hydrochloride		Adrenergic Receptor
	DL-Adrenaline Hydrochloride is the hydrochloride salt of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing activities.		Adrenergic Receptor
T6422	Brimonidine Tartrate	AGN190342 tartrate,304 tartrate,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate	Adrenergic Receptor
	Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hyperten...		Adrenergic Receptor
T19870	Aceclidine	3-Acetoxyquinuclidine,1-azabicyclo[2.2.2]octan-3-yl acetate,NSC657843,3-quinuclidinyl acetate,NSC-657843,Glaucostat,NSC 657843,Quinuclidin-3-yl acetate	AChR
	Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular pressure.		AChR
T10358	Netarsudil Dihydrochloride	AR-13324 Dihydrochloride	ROCK
	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.		ROCK
T21371	Apraclonidine hydrochloride	Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum	Adrenergic Receptor
	Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glauco...		Adrenergic Receptor
T15719	Latanoprostene bunod	LBN,NCX116	Others
	Latanoprostene bunod (LBN) is nitric oxide (NO)-donating prostaglandin F2a analog and is a topical ophthalmic therapeutic. It is used for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma o...		Others
T67746	IMS2186		Others
	IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the...		Others
T22029	AL 34662		5-HT Receptor , Adrenergic Receptor
	AL 34662 is a selective and potent 5-HT2A receptor agonist with IC50s of 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively.AL 34662 is also a low affinity α-1D adrenergic agonist, with an EC50 of 0.4 μM....		5-HT Receptor , Adrenergic Receptor
T2403	Bromfenac sodium hydrate	Bromfenac sodium,Bromfenac monosodium salt sesquihydrate	COX
	Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic admi...		COX
T25483	H-0106 Dihydrochloride	H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride
	H-0106 Dihydrochloride is an inhibitor of ROCK that acts by applying strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T13955	Unoprostone		Others
	Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.		Others
T10358L2	Netarsudil mesylate	AR-13324 (mesylate)	Others
	Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.		Others
T25482	H-0104 Dihydrochloride	H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl
	H-0104 Dihydrochloride is an inhibitor of ROCK that acts by applying potent intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T37991	15-keto Prostaglandin F2α	15-keto Prostaglandin F2α,15-keto PGF2α	Endogenous Metabolite , Prostaglandin Receptor
	15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits.		Endogenous Metabolite , Prostaglandin Receptor
T71120	AR-13503
	AR-13503, is an metabolite of Netarsudil (AR-11324), is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure.