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Apraclonidine hydrochloride

Catalog No. T21371 CAS 73218-79-8

Synonyms: Iopidine, ALO 2145, Apraclonidina, P-aminoclonidine, 4-Aminoclonidine, Apraclonidine HCl, Apraclonidinum

Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glaucoma therapy.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Apraclonidine hydrochloride Chemical Structure

Apraclonidine hydrochloride, CAS 73218-79-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 222.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 493.00
500 mg	In stock	$ 1,070.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 98.01%

Biological Description

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Description	Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glaucoma therapy.
In vitro	Apraclonidine hydrochloride penetrates the cornea and blood-brain barrier to a lesser extent[2].
In vivo	Apraclonidine hydrochloride elevats intraocular pressure as well as glaucoma. Apraclonidine reduces aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery[2]. Apraclonidine (1.15%) causes a 98% inhibition of PGE2-induced aqueous flare elevationy[3].

Synonyms	Iopidine, ALO 2145, Apraclonidina, P-aminoclonidine, 4-Aminoclonidine, Apraclonidine HCl, Apraclonidinum
Molecular Weight	281.57
Formula	C9H11Cl3N4
CAS No.	73218-79-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (399.5 mM), Sonication is recommended.

H2O: 11.2 mg/mL (40.0 mM)

References and Literature

1. Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132. 2. Searles RV, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999;58(4):220‐226. 3. Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci 4. Cooper-Knock J, Pepper I, Hodgson T, Sharrack B. Early diagnosis of Horner syndrome using topical apraclonidine. J Neuroophthalmol. 2011 Sep;31(3):214-6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library GPCR Compound Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library FDA-Approved Drug Library Neuronal Signaling Compound Library Bioactive Compounds Library Max

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TD-5471 hydrochloride Prazosin Nicergoline Brefonalol HCl Oxyfedrine L-form HCl Brimonidine Desipramine hydrochloride Urapidil hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Apraclonidine hydrochloride 73218-79-8 GPCR/G Protein Neuroscience Adrenergic Receptor Iopidine ALO 2145 ALO2145 Apraclonidine Hydrochloride Apraclonidina P-aminoclonidine 4-Aminoclonidine Apraclonidine HCl Apraclonidinum ALO-2145 inhibitor inhibit

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