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Brimonidine Tartrate

Catalog No. T6422 CAS 70359-46-5

Synonyms: AGN190342 tartrate, 304 tartrate, AGN190342 (tartrate), UK 14304 (tartrate), UK14304 tartrate

Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension.

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Brimonidine Tartrate, CAS 70359-46-5

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 41.00
500 mg	In stock	$ 126.00

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Purity: 99.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension.
Targets&IC50	α2A-adrenoceptor:0.45 nM(EC50)

Synonyms	AGN190342 tartrate, 304 tartrate, AGN190342 (tartrate), UK 14304 (tartrate), UK14304 tartrate
Molecular Weight	442.22
Formula	C15H16BrN5O6
CAS No.	70359-46-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 199 mM

H2O: 56.53mM

References and Literature

1. WoldeMussie E, et al. Invest Ophthalmol Vis Sci, 2001, 42(12), 2849-2855. 2. Gao H, et al. Arch Ophthalmol, 2002, 120(6), 797-803. 3. Greenfield DS, et al. J Glaucoma, 1997, 6(4), 250-258. 4. Ahmed FA, et al. Brain Res, 2001, 913(2), 133-139. 5. Lafuente MP, et al. Exp Eye Res, 2002, 74(2), 181-189.

Citations

1. Xu C, Zhou Y, Liu Y, et al.Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons.Nature Communications.2024, 15(1): 1990.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library EMA Approved Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Bioactive Compounds Library Max Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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