heat — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36865	Heat Shock Protein Inhibitor II
	Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hs...
T22837	HEAT hydrochloride		Others
	HEAT hydrochloride is an α1-adrenoceptor antagonist.		Others
T2444	KNK437	Heat Shock Protein Inhibitor I	HSP
	KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).		HSP
TQ0280	Feretoside		HSP
	Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).		HSP
T8668	HM03		HSP
	HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.		HSP
T3594	ML346		HSP
	ML346 is a novel activator of Hsp70.		HSP
T4125	HSF1A		HSP
	HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.		HSP
T8189	Dihydroberberine		Potassium Channel , HSP , HER
	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interacti...		Potassium Channel , HSP , HER
T6248	XL888		HSP
	XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis....		HSP
T21883	Gedunin		HSP
	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.		HSP
T3652	KRIBB11		Apoptosis , HSP
	KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.		Apoptosis , HSP
T3487	HSP70-IN-1		Others , HSP
	HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).		Others , HSP
T5008	Teprenone	Tetraprenylacetone,Geranylgeranylacetone	HSP
	Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).		HSP
T3527	TRC051384	TRC 051384	HSP
	TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ...		HSP
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T6855	HA15		Apoptosis , GPR , Others , HSP , Autophagy
	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.		Apoptosis , GPR , Others , HSP , Autophagy
T6558	KW-2478	KW2478	HSP
	KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.		HSP
T7010	VER-155008	VER155008	GPR , HSP , Autophagy
	VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.		GPR , HSP , Autophagy
T16994	Pimitespib	TAS-116	HSP
	Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).		HSP
T10860	Col003		HSP
	Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the investigation of fibrosis.		HSP