guinea-pigs — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0383	Fenspiride hydrochloride	Fenspiride HCl,Pneumorel,Fluiden,Decaspiride	Adrenergic Receptor , PDE , Histamine Receptor
	Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of chronic and acute inflammatory ...		Adrenergic Receptor , PDE , Histamine Receptor
T16965	Symetine	L 16726	Parasite
	Symetine（L 16726） is a small molecule compound with antiparasitic activity that can be used to study amoebic liver abscesses in guinea pigs.		Parasite
T13331	WAY127093B racemate		PDE
	WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.		PDE
T31195	Dalcotidine	KU 1257,KU-1257	Histamine Receptor
	Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value f...		Histamine Receptor
T6S0033	Crotonoside	Isoguanosine,2-HYDROXYADENOSINE	Others , FLT , HDAC
	1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim...		Others , FLT , HDAC
T23283	2-Methoxyidazoxan monohydrochloride	RX 821002 hydrochloride	Adrenergic Receptor
	L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity ...		Adrenergic Receptor
T4535L	Etomoxir	(R)-(+)-Etomoxir	Antioxidant , CPT
	Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting CPT-1a and inhibits palmitate oxidation in humans, rats, and guinea pigs. Etomoxir has an inhibitory eff...		Antioxidant , CPT
T4953	Neotuberostemonine		NOS
	Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruit...		NOS
TP1358L	Peptide M acetate	Peptide M acetate(110652-62-5 free base)	Others
	Peptide M acetate is a synthetic amino acid (18 amino acids in length which correspond to the amino acid positions 303-322 of bovine S-antigen: DTNLASSTIIKEGIDKTV). Peptide M acetate is capable of inducing experimental a...		Others
T68109	Moxipraquine		Antibiotic
	Moxipraquine is a novel 8-aminoquinolone compound with anti-infective activity against Trypanosoma cruzi. Moxipraquine effectively inhibited parasitemia but did not eradicate infections in mice or guinea pigs. Moxipraqui...		Antibiotic
T33647L	Nesosteine Lithium	Nesosteine Lithium(84233-61-4 Free baes)
	Nesosteine Lithium is a novel mucoregulatory that inhibits Herxheimer microconvulsions in guinea pigs and inhibits ovalbumin-induced histamine release from sensitized trachea.Nesosteine Lithium protects against ovalbumin...
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T15647	Tipelukast	MN 001,KCA 757	Leukotriene Receptor
	Tipelukast (KCA 757) is a novel orally available leukotriene receptor antagonist with anti-inflammatory activity that reduces fibrosis and down-regulates TIMP-1, type 1 collagen.Tipelukast is used in the study of asthma.		Leukotriene Receptor
T30110	AR 12456	AR12456,AR-12456
	AR-12456 is a Trapidil derivative that prevents serum hyperlipidemia in guinea pigs.
T23829	Btm 1042	Btm1042,Btm-1042
	Btm 1042 is an antispasmodic drug. It has been found to depress twitch responses in the ileum of guinea pigs.
T32770	Linsidomine	CV 664
	Lincydomine is a smooth muscle relaxant, beneficial to the treatment of unstable angina pectoris, but also can open the respiratory tract of humans and guinea pigs.
T27915	LY 302148	LY-302148,LY302148
	LY 302148 , a 5-HT1F receptor agonist, inhibits neurogenic dural inflammation in guinea pigs. It has potential for migraine therapeutics.
T38266	Nirogacestat dihydrobromide
	Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmaco...
T82424	Experimental allergic encephalitogenic peptide (human)
	Experimental allergic encephalitogenic peptide (human), an EAE peptide, induces encephalomyelitis in guinea pigs [1].
T70106	F-050
	F-050 is a biochemical that has been shown to inhibit platelet aggregation induced by CaCl2, arachidonic acid, collagen, adenosine diphosphate (ADP) and thrombin in guinea pigs, rabbits and rats in vitro. F-050 may be us...