farnesoid — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1789	Obeticholic Acid	INT-747,6-Ethylchenodeoxycholic acid,6-ECDCA	FXR , Autophagy
	Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.		FXR , Autophagy
T2601	Vidofludimus	SC12267,4sc-101	Dehydrogenase , DNA/RNA Synthesis , Interleukin
	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).		Dehydrogenase , DNA/RNA Synthesis , Interleukin
T8471	Vonafexor	EYP001,PLX007,pxl007	FXR , HBV
	Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects		FXR , HBV
T7886	Nidufexor		FXR , Autophagy
	Nidufexor is an agonist for the farnesoid X receptor (FXR).		FXR , Autophagy
T2233	GW 4064		FXR , Autophagy
	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).		FXR , Autophagy
T11428	Glyco-Obeticholic acid		FXR
	Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).		FXR
T13092	Tauro-Obeticholic acid		FXR
	Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).		FXR
T2015	Fexaramine		FXR , Autophagy
	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.		FXR , Autophagy
T7436	Cilofexor		FXR , Autophagy
	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.		FXR , Autophagy
T11426	Gly-β-MCA		FXR
	Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.		FXR
T8818	TC-G 1005		GPCR19
	TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.		GPCR19
T27316	Fexarine
	Fexarine is a potent, selective agonist of farnesoid X receptor.
T27492	GSK-8062	GSK 8062
	GSK-8062 is an agonist of farnesoid X receptor (FXR).
T27315	Fexaramate
	Fexaramate is a potent, selective agonist of farnesoid X receptor.
T13093	Tauro-β-muricholic acid sodium	T-βMCA sodium	FXR
	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).		FXR
T2968L	Hyodeoxycholic acid sodium salt	Sodium hyodeoxycholate,HDCA sodium
	Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 sy...
T11661	INT-767		FXR , GPCR19
	INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.		FXR , GPCR19
T37416	Tauro-α-muricholic Acid (sodium salt)
	Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but h...
T75538	Alismanol M
	Alismanol M, a protostane-type triterpenoid isolated from the rhizome of Alisma orientale, functions as a farnesoid X receptor (FXR) agonist with an EC50 value of 50.25 μM. It is utilized in researching cholestasis and n...
T69724	Cilofexor tromethamine
	Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilof...