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Obeticholic Acid

Catalog No. T1789 CAS 459789-99-2

Synonyms: INT-747, 6-Ethylchenodeoxycholic acid, 6-ECDCA

Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.

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Obeticholic Acid, CAS 459789-99-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 75.00
50 mg	In stock	$ 101.00
100 mg	In stock	$ 166.00
200 mg	In stock	$ 288.00
500 mg	In stock	$ 531.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.97%

Purity: 99.88%

Purity: 99.78%

Purity: 99.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
Targets&IC50	FXR:99 nM(EC50)

Synonyms	INT-747, 6-Ethylchenodeoxycholic acid, 6-ECDCA
Molecular Weight	420.63
Formula	C26H44O4
CAS No.	459789-99-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 78 mg/mL (185.4 mM)

Ethanol: 78 mg/mL (185.4 mM)

References and Literature

1. Pellicciari R, et al. J Med Chem. 2002, 45(17), 3569-3572. 2. Wang XX, et al. Am J Physiol Renal Physiol. 2009, 297(6), F1587-1596. 3. Verbeke L, et al. Hepatology. 2014, 59(6), 2286-2298.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Ferroptosis Compound Library FDA-Approved Drug Library Preclinical Compound Library Metabolism Compound Library Anti-Metabolism Disease Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Obeticholic Acid 459789-99-2 Autophagy Metabolism FXR INT-747 orally NR1H4 active farnesoid INT 747 receptor Inhibitor 6-Ethylchenodeoxycholic acid 6-ECDCA inhibit INT747 inhibitor

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