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Tauro-β-muricholic acid sodium

Catalog No. T13093 CAS 145022-92-0

Synonyms: T-βMCA sodium

Tauro-β-muricholic Acid sodium is a Endogenous Metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).

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Tauro-β-muricholic acid sodium, CAS 145022-92-0

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Purity: 98%

Biological Description

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Description	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
Targets&IC50	FXR:40 μM
In vitro	In the CRC cell line HT29, T-βMCA sodium inhibits FXR reporter activity (EC50 ~10 μM)[3].In HT29 and HCT116 cells, T-βMCA sodium dose-dependently increases WNT signaling [3]. T-βMCA sodium induces proliferation and DNA damage in Lgr5+ cells[3].
In vivo	T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].

Synonyms	T-βMCA sodium
Molecular Weight	538.7
Formula	C26H45NNaO7S
CAS No.	145022-92-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35. 2. Wahlström A, et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017 Feb;58(2):412-419. 3. Fu T, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019 Feb 21;176(5):1098-1112.e18.

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Keywords

Tauro-β-muricholic acid sodium 145022-92-0 Metabolism FXR T-βMCA sodium Tauroβmuricholic acid sodium Tauro β muricholic acid sodium Inhibitor inhibitor inhibit

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