Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Tauro-β-muricholic Acid sodium is a Endogenous Metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
Description | Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM). |
Targets&IC50 | FXR:40 μM |
In vitro | In the CRC cell line HT29, T-βMCA sodium inhibits FXR reporter activity (EC50 ~10 μM)[3].In HT29 and HCT116 cells, T-βMCA sodium dose-dependently increases WNT signaling [3]. T-βMCA sodium induces proliferation and DNA damage in Lgr5+ cells[3]. |
In vivo | T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3]. |
Synonyms | T-βMCA sodium |
Molecular Weight | 538.7 |
Formula | C26H45NNaO7S |
CAS No. | 145022-92-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Tauro-β-muricholic acid sodium 145022-92-0 Metabolism FXR T-βMCA sodium Tauroβmuricholic acid sodium Tauro β muricholic acid sodium Inhibitor inhibitor inhibit