cystic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16681	Nesolicaftor	PTI-428	CFTR , Autophagy
	Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.		CFTR , Autophagy
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
T14935	Elexacaftor	VX-445	CFTR , Autophagy
	Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.		CFTR , Autophagy
T3135	KM11060		CFTR , Autophagy
	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.		CFTR , Autophagy
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T5312	CFTR corrector 2	FDL169	CFTR , Autophagy
	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.		CFTR , Autophagy
T2451	GlyH-101	GlyH 101	CFTR , Autophagy
	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.		CFTR , Autophagy
T4503	Talniflumate	Somalgen	Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
	Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T7083	GLPG1837	ABBV-974	CFTR , Autophagy
	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.		CFTR , Autophagy
T1874	PPQ-102	PPQ102,CFTR Inhibitor,PPQ 102	CFTR , Autophagy
	PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).		CFTR , Autophagy
T2588	Ivacaftor	Ivacaftor (VX-770),VX-770	CFTR , Autophagy
	Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.		CFTR , Autophagy
T2486	IOWH-032	IOWH032,IOWH 032	CFTR , Autophagy
	IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.		CFTR , Autophagy
T10591	BPO-27 racemate	BPO-27 (racemate)	CFTR , Autophagy
	BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.		CFTR , Autophagy
T2595	Lumacaftor	VX-809,VRT 826809	CFTR , Autophagy
	Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).		CFTR , Autophagy
T6540	Ibuprofen Lysine	Neoprofen	COX
	Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.		COX
T1394	Ibuprofen	Brufen,(±)-Ibuprofe,Motrin,Advil	COX
	Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...		COX
T2355	CFTR(inh)-172	CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172	CFTR , Autophagy
	CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.		CFTR , Autophagy
T15543	IA-Alkyne	N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne	TRP/TRPV Channel
	IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of r...		TRP/TRPV Channel
T2263	Tezacaftor	VX661	CFTR , Autophagy
	Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.		CFTR , Autophagy