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BPO-27 racemate

Name: BPO-27 racemate
Brand: TargetMol
SKU: T10591
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10591Cas No. 1314873-02-3

Alias BPO-27 (racemate)

BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.

BPO-27 racemate

🥰Excellent

Purity: 98.86%

Catalog No. T10591Alias BPO-27 (racemate)Cas No. 1314873-02-3

BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$119	In Stock
10 mg	$178	In Stock
25 mg	$295	In Stock
50 mg	$431	In Stock
100 mg	$595	In Stock
200 mg	$798	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.86%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.
Targets&IC50	CFTR:8 nM
In vitro	The R enantiomer of BPO-27 inhibits CFTR chloride conductance (IC50: 4 nM), while S enantiomer is inactive. In vitro metabolic stability in hepatic microsomes shows both enantiomers as stable, with less than 5% metabolism in 4 h [1]. (R)-BPO-27 binds near the canonical ATP binding site. Whole-cell patch-clamp studies show linear CFTR currents with a voltage-independent (R)-BPO-27 block mechanism. At a concentration of (R)-BPO-27 that inhibits CFTR chloride current by 50%, the EC50 for ATP activation of CFTR increases from 0.27 to 1.77 mM [2].
In vivo	Following bolus intraperitoneal administration of BPO-27 in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in the kidney [1].
Synonyms	BPO-27 (racemate)

Chemical Properties

Molecular Weight	548.34
Formula	C₂₆H₁₈BrN₃O₆
Cas No.	1314873-02-3
Smiles	Cn1c2c3C(Oc4ccc(cc4-n3c(-c3ccccc3)c2c(=O)n(C)c1=O)C(O)=O)c1ccc(Br)o1
Relative Density.	1.68 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (100.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8237 mL	9.1184 mL	18.2369 mL	91.1843 mL
5 mM	0.3647 mL	1.8237 mL	3.6474 mL	18.2369 mL
10 mM	0.1824 mL	0.9118 mL	1.8237 mL	9.1184 mL
20 mM	0.0912 mL	0.4559 mL	0.9118 mL	4.5592 mL
50 mM	0.0365 mL	0.1824 mL	0.3647 mL	1.8237 mL
100 mM	0.0182 mL	0.0912 mL	0.1824 mL	0.9118 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc