Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 492.00 | |
50 mg | In stock | $ 718.00 | |
100 mg | In stock | $ 992.00 | |
200 mg | In stock | $ 1,330.00 | |
500 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 229.00 |
Description | BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM. |
Targets&IC50 | CFTR:8 nM |
In vitro | The R enantiomer of BPO-27 inhibits CFTR chloride conductance (IC50: 4 nM), while S enantiomer is inactive. In vitro metabolic stability in hepatic microsomes shows both enantiomers as stable, with less than 5% metabolism in 4 h [1]. (R)-BPO-27 binds near the canonical ATP binding site. Whole-cell patch-clamp studies show linear CFTR currents with a voltage-independent (R)-BPO-27 block mechanism. At a concentration of (R)-BPO-27 that inhibits CFTR chloride current by 50%, the EC50 for ATP activation of CFTR increases from 0.27 to 1.77 mM [2]. |
In vivo | Following bolus intraperitoneal administration of BPO-27 in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in the kidney [1]. |
Synonyms | BPO-27 (racemate) |
Molecular Weight | 548.34 |
Formula | C26H18BrN3O6 |
CAS No. | 1314873-02-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (10.94 mM), sonification/heating is recommended.
You can also refer to dose conversion for different animals. More
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