circadian — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22891	KL001	KL 001,KL-001	Others
	KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced glu...		Others
T14004	1A-116		Rho
	1A-116 is a specific inhibitor of Rac1 .		Rho
T9608	KL201		Others
	KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1].		Others
TP1264	Prolylleucine	((Benzyloxy)carbonyl)-L-prolyl-D-leucine	Others
	Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) is a dipeptide containing branched-chain amino acids.		Others
T9356	(E/Z)-GO289		Casein Kinase
	(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function...		Casein Kinase
T3495	Tasimelteon	VEC-162,BMS-214778	Melatonin Receptor , MT Receptor
	Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.		Melatonin Receptor , MT Receptor
T73573	CLK8		Others
	CLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-...		Others
T27931	LY2033298	LY 2033298,LY-2033298	AChR
	LY2033298, a positive allosteric modulator of muscarine M4 receptor, enhances the inhibitory effect of oximoline on light-induced phase shift in circadian activity in hamsters and can be used in neurosystem-related disea...		AChR
T32401	KL044	KL 044,KL-044	Others
	KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP/PKA/CREB pathway.		Others
T3685	SR9009	Stenabolic,REV-ERB Agonist II	Autophagy
	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during...		Autophagy
T71896	Brevicompanine B
	Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various gen...
T27430	GR 196429	GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429
	GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice.
T70812	PF-05236216 hydrochloride
	PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice.
T82587	Delta (Phospho) Sleep Inducing Peptide	DSIP-P
	Delta (Phospho) Sleep Inducing Peptide (DSIP-P), a peptide that promotes sustained sleep, elicits alterations in circadian locomotor activity in rats [1] [2] [3].
TN1812	Jujuboside B1		5-HT Receptor
	Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides may be good source of lead compounds for n...		5-HT Receptor
T80849	VU661
	VU661, a redox-active phenazine carboxamide, modulates circadian rhythms by inducing period lengthening.
T63375	FT709
	FT709 is a selective and potent inhibitor of USP9X (IC50: 82 nM). Among others, USP9X is associated with centrosome function, EGF receptor degradation, chromosome alignment during mitosis, chemosensitization and circadia...
T17095	TIK-301	PD-6735,LY-156735	5-HT Receptor
	TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an...		5-HT Receptor
TP1980	Neuromedin S(rat)	Neuromedin S (rat)
	Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent en...
T38433	KS15
	KS15 is a chemical compound that acts as an inhibitor on the interactions between cryptochromes, specifically CRY1 and CRY2, and the CLOCK: BMAL1 heterodimer. This compound, with an EC50 value of 4.9 μM, hinders the feed...