caspase-independent — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1979	AVN-944	VX-944	Dehydrogenase
	AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.		Dehydrogenase
T8468	CIL62		Caspase
	CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].		Caspase
T17192	Ubiquitin Isopeptidase Inhibitor I, G5	NSC144303	Apoptosis
	Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively).		Apoptosis
T22012	7BIO		FLT , DYRK , Aurora Kinase
	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.		FLT , DYRK , Aurora Kinase
T16522	Phenoxodiol	Dehydroequol,Idronoxil,Haginin E	Apoptosis , IAP , Caspase , Topoisomerase , p53
	Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apop...		Apoptosis , IAP , Caspase , Topoisomerase , p53
T34847	Thiobenzanilide 63T	63T,Thiobenzanilide63T,Thiobenzanilide-63T
	Thiobenzanilide 63T is a small molecule that selectively induces cancer cell death in a caspase-independent pathway,
TN1837	Kuguaglycoside C		PARP , Caspase
	Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.		PARP , Caspase
T72932	Triphen diol
	Triphen Diol, a phenol diol derivative, exhibits potent anticancer properties against pancreatic cancer and cholangiocarcinoma, efficiently inducing pancreatic cell apoptosis via both caspase-mediated and caspase-indepen...
T14003	15-Acetoxyscirpenol		Caspase
	15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activat...		Caspase
TN4903	Regiolone		Caspase
	Regiolone demonstrates phytotoxicity. Regiolone also has anti-proliferative and apoptotic activities, it can induce apoptosis in MCF-7 cells through the caspase-3 independent pathway.		Caspase
T25032	ALC67	ALC-67,ALC 67
	ALC67 has a promising anticancer activity that results in the recent discovery of a series of 3-propionyl thiazolidine-4-carboxylic acid ethyl esters as a family of novel antiproliferative agents. It is an activator of t...
T39176	PB28
	PB28 is a cyclohexylpiperazine derivative that functions as a potent and highly selective agonist of the sigma 2 (σ2) receptor, exhibiting a Ki (binding affinity) of 0.68 nM. At the same time, PB28 acts as an antagonist ...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ...