c-abl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39827	c-ABL-IN-1
	C-ABL-IN-1 is a new and specific inhibitor of the c-Abl protein, which effectively prevents the progression of neurodegeneration observed in Parkinson's disease.
T21785	AG957		Bcr-Abl
	Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].		Bcr-Abl
T61546	c-ABL-IN-3
	c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer [1]. The ac...
T79716	c-ABL-IN-5		Bcr-Abl
	C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier permeability, metabolic stability, and pharmacokinetic profiles. When labeled w...		Bcr-Abl
T61128	c-ABL-IN-2
	C-ABL-IN-2 is a highly effective inhibitor of the c-Abl protein, which plays a significant role in the development of several diseases, including cancer. This compound exhibits promise for investigating neurodegenerative...
T4320	Flumatinib	HHGV678	Bcr-Abl , PDGFR , c-Kit
	Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.		Bcr-Abl , PDGFR , c-Kit
T62065	c-ABL-IN-4
	c-ABL-IN-4 is a potent inhibitor of c-Abl.
T7861	Flumatinib mesylate	HHGV678 mesylate	Bcr-Abl , PDGFR , c-Kit
	Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.		Bcr-Abl , PDGFR , c-Kit
T4191	Multi-kinase inhibitor 1	Multi-kinase inhibitor I	Others , Bcr-Abl , PDGFR , c-Kit
	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.		Others , Bcr-Abl , PDGFR , c-Kit
T11641	N-Desmethyl imatinib	Imatinib metabolite N-Desmethyl imatinib,Norimatinib	Bcr-Abl , PDGFR , c-Kit , Drug Metabolite
	N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.		Bcr-Abl , PDGFR , c-Kit , Drug Metabolite
T6230	Imatinib	STI571,CGP057148B,ST-1571	SARS-CoV , Bcr-Abl , PDGFR , c-Kit , Autophagy
	Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit with oral activity. Imatinib has antitumor activity for the tre...		SARS-CoV , Bcr-Abl , PDGFR , c-Kit , Autophagy
T4053	AST 487	NVP-AST 487	VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
	AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.		VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
T1621	Imatinib Mesylate	ST-1571 Mesylate,STI-571,CGP-57148B	Bcr-Abl , PDGFR , c-Kit , Autophagy
	Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, respectively).		Bcr-Abl , PDGFR , c-Kit , Autophagy
T4618	BGG463	K 0859	Bcr-Abl , CDK
	BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.		Bcr-Abl , CDK
T6348	NVP-BHG712		Raf , Bcr-Abl , Src , Ephrin Receptor
	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respecti...		Raf , Bcr-Abl , Src , Ephrin Receptor
T3935	1-Naphthyl PP1	1-NA-PP 1	Src
	1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)		Src
T15164	DPH		Bcr-Abl
	DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation.		Bcr-Abl
T22552L	AD57		Bcr-Abl , Src
	AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.		Bcr-Abl , Src
T6311	Bafetinib	NS-187,INNO-406	Bcr-Abl , Src , Autophagy
	Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.		Bcr-Abl , Src , Autophagy
T7371	1-Naphthyl PP1 hydrochloride	1-NA-PP 1 hydrochloride	Src
	1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases v-Src		Src