Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
2 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 75.00 | |
10 mg | In stock | $ 119.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 487.00 | |
100 mg | In stock | $ 663.00 | |
200 mg | In stock | $ 967.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 129.00 |
Description | DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation. |
In vitro | DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation. DPH binds to the myristoyl binding site. It also prevents the formation of the bent conformation of the αI helix through steric hindrance. Which is a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site [1]. |
Molecular Weight | 336.32 |
Formula | C18H13FN4O2 |
CAS No. | 484049-04-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (267.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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DPH 484049-04-9 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl inhibitor inhibit