activating — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1046L	PAR-2 Activating Peptide acetate	SLIGRL-NH2 acetate,PAR-2 Activating Peptide acetate(171436-38-7 free base),Protease-Activated Receptor-2 Activating Peptide acetate	Protease-activated Receptor
	PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).		Protease-activated Receptor
TP2411	Sperm-activating peptide 1
	Sperm-activating peptide 1 is a bioactive chemical.
TP1046	SLIGRL-NH2	Protease-Activated Receptor-2 Activating Peptide	Protease-activated Receptor
	SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a protease-activated receptor-2 (PAR-2) agonist that induces non-histaminergic pruritus.		Protease-activated Receptor
T2503	PAC-1	Procaspase activating compound 1	Apoptosis , Caspase , Autophagy
	PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.		Apoptosis , Caspase , Autophagy
T81372	Proteasome-activating peptide 1
	Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m...
T76243	Proteasome-activating peptide 1 TFA
	Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,...
T5374	NAcM-OPT		E1/E2/E3 Enzyme , NEDD8
	NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).		E1/E2/E3 Enzyme , NEDD8
T24136	Heclin		E1/E2/E3 Enzyme
	Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.		E1/E2/E3 Enzyme
T80069	PACAP (6-27) (human, ovine, rat)	Pituitary adenylate cyclase-activating peptide (6-27)
	PACAP (6-27) (human, ovine, rat) serves as an antagonist for the PACAP receptor, inhibiting the catecholamine response of the canine adrenal gland to vasoactive intestinal peptide (VIP). This compound holds promise for r...
T5199	COH000		E1/E2/E3 Enzyme
	COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).		E1/E2/E3 Enzyme
T16699	PYZD-4409		Others , E1/E2/E3 Enzyme
	PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.		Others , E1/E2/E3 Enzyme
T16102	ML-792		E1/E2/E3 Enzyme
	ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...		E1/E2/E3 Enzyme
T16901	SMIP004		Apoptosis , Others , E1/E2/E3 Enzyme
	SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.		Apoptosis , Others , E1/E2/E3 Enzyme
T3517	RO8994		Mdm2 , E1/E2/E3 Enzyme , p53
	RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).		Mdm2 , E1/E2/E3 Enzyme , p53
T8428	Subasumstat	TAK-981	E1/E2/E3 Enzyme
	Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.		E1/E2/E3 Enzyme
T6629	PYR-41	PYR41,PYR 41	Apoptosis , E1/E2/E3 Enzyme
	PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.		Apoptosis , E1/E2/E3 Enzyme
T7379	2-D08		E1/E2/E3 Enzyme , TAM Receptor
	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.		E1/E2/E3 Enzyme , TAM Receptor
T75902	SLIGRL-NH2 TFA	Protease-Activated Receptor-2 Activating Peptide TFA
	SLIGRL-NH2 TFA, also known as Protease-Activated Receptor-2 Activating Peptide TFA, is a Protease-Activated Receptor-2 (PAR-2) agonist [1].
T13244	Ubiquitination-IN-1		Others
	Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).		Others
T9236	WSB1 Degrader 1		Others , E1/E2/E3 Enzyme
	WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.		Others , E1/E2/E3 Enzyme