Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 82.00 | |
2 mg | In stock | $ 118.00 | |
5 mg | In stock | $ 183.00 | |
10 mg | In stock | $ 278.00 | |
25 mg | In stock | $ 463.00 | |
50 mg | In stock | $ 667.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 136.00 |
Description | SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells. |
In vitro | SMIP004 reduces the levels of positive cell cycle regulators upregulates cyclin-dependent kinase inhibitors. It also causes G1 arrest, inhibition of colony formation in soft agar, and cell death [2]. |
In vivo |
In SCID mice, SMIP004 effectively inhibits the growth of prostate and breast cancer xenografts [2]. |
Molecular Weight | 205.3 |
Formula | C13H19NO |
CAS No. | 143360-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (487.09 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SMIP004 143360-00-3 Apoptosis Others Ubiquitination E1/E2/E3 Enzyme E1 activating enzyme Inhibitor Ubiquitin ligase E2 conjugating enzyme Ubiquitin activating enzyme inhibit E3 ligating enzyme SMIP 004 SMIP-004 Ubiquitin conjugating enzyme inhibitor