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SMIP004

Catalog No. T16901 CAS 143360-00-3

SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.

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SMIP004, CAS 143360-00-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 82.00
2 mg	In stock	$ 118.00
5 mg	In stock	$ 183.00
10 mg	In stock	$ 278.00
25 mg	In stock	$ 463.00
50 mg	In stock	$ 667.00
1 mL * 10 mM (in DMSO)	In stock	$ 136.00

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Purity: 99.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
In vitro	SMIP004 reduces the levels of positive cell cycle regulators upregulates cyclin-dependent kinase inhibitors. It also causes G1 arrest, inhibition of colony formation in soft agar, and cell death [2].
In vivo	In SCID mice, SMIP004 effectively inhibits the growth of prostate and breast cancer xenografts [2].

Molecular Weight	205.3
Formula	C13H19NO
CAS No.	143360-00-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (487.09 mM)

References and Literature

1. Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38(1):76. 2. Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Ubiquitination Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SMIP004 143360-00-3 Apoptosis Others Ubiquitination E1/E2/E3 Enzyme E1 activating enzyme Inhibitor Ubiquitin ligase E2 conjugating enzyme Ubiquitin activating enzyme inhibit E3 ligating enzyme SMIP 004 SMIP-004 Ubiquitin conjugating enzyme inhibitor

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