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2-D08

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.

Catalog No. T7379Cas No. 144707-18-6

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Purity:98.58%

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COA HNMR LCMS

2-D08

Catalog No. T7379Cas No. 144707-18-6

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.

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Pack Size	Price	Availability
5 mg	$52	In Stock
10 mg	$89	In Stock
25 mg	$189	In Stock
50 mg	$297	In Stock
100 mg	$538	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock

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Product Introduction

Bioactivity

Description	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
Targets&IC50	Axl:0.49 nM
In vitro	2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474.[1] It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-β (Aβ) (1-42) aggregation and Aβ-induced toxicity in PC12 cells. It also has antioxidant properties[2].

Chemical Properties

Molecular Weight	270.24
Formula	C₁₅H₁₀O₅
Cas No.	144707-18-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 150 mg/mL (555.06 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7004 mL	18.5021 mL	37.0041 mL	185.0207 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL	37.0041 mL
10 mM	0.3700 mL	1.8502 mL	3.7004 mL	18.5021 mL
20 mM	0.1850 mL	0.9251 mL	1.8502 mL	9.2510 mL
50 mM	0.0740 mL	0.3700 mL	0.7401 mL	3.7004 mL
100 mM	0.0370 mL	0.1850 mL	0.3700 mL	1.8502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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