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2-D08

Catalog No. T7379 CAS 144707-18-6

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.

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2-D08, CAS 144707-18-6

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Purity: 98%

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Description	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
Targets&IC50	Axl:0.49 nM
In vitro	2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474.[1] It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-β (Aβ) (1-42) aggregation and Aβ-induced toxicity in PC12 cells. It also has antioxidant properties[2].

Molecular Weight	270.24
Formula	C15H10O5
CAS No.	144707-18-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 150 mg/mL (555.06 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kim Y , Nagy K , Keyser S , et al. An Electrophoretic Mobility Shift Assay Identifies a Mechanistically Unique Inhibitor of Protein Sumoylation[J]. Chemistry & Biology, 2013, 20(4):604-613. 2. Marsh D T , Das S , Ridell J , et al. Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08).[J]. Bioorganic & Medicinal Chemistry, 2017, 25(14). 3. Kim Y S , Keyser S G L , Schneekloth J S . Synthesis of 2’,3’,4’-trihydroxyflavone (2-D08), an Inhibitor of Protein Sumoylation[J]. Bioorganic & medicinal chemistry letters, 2014, 24(4).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Anti-Obesity Compound Library Inhibitor Library Immunology/Inflammation Compound Library Kinase Inhibitor Library Stem Cell Differentiation Compound Library Ubiquitination Compound Library Apoptosis Compound Library Anti-Aging Compound Library

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Keywords

2-D08 144707-18-6 蛋白酪氨酸激酶泛素化 E1/E2/E3 Enzyme TAM Receptor Ubiquitin ligase Axl Tyro3 E3 ligating enzyme Ubiquitin activating enzyme Inhibitor E1 activating enzyme inhibit 2-D-08 2 D08 2D08 E2 conjugating enzyme Mer Ubiquitin conjugating enzyme inhibitor

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