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2-D08

Catalog No. T7379 CAS 144707-18-6

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.

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2-D08, CAS 144707-18-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 189.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 538.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 98%

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Description	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
Targets&IC50	Axl:0.49 nM
In vitro	2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474.[1] It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-β (Aβ) (1-42) aggregation and Aβ-induced toxicity in PC12 cells. It also has antioxidant properties[2].

Molecular Weight	270.24
Formula	C15H10O5
CAS No.	144707-18-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 150 mg/mL (555.06 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kim Y , Nagy K , Keyser S , et al. An Electrophoretic Mobility Shift Assay Identifies a Mechanistically Unique Inhibitor of Protein Sumoylation[J]. Chemistry & Biology, 2013, 20(4):604-613. 2. Marsh D T , Das S , Ridell J , et al. Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08).[J]. Bioorganic & Medicinal Chemistry, 2017, 25(14). 3. Kim Y S , Keyser S G L , Schneekloth J S . Synthesis of 2’,3’,4’-trihydroxyflavone (2-D08), an Inhibitor of Protein Sumoylation[J]. Bioorganic & medicinal chemistry letters, 2014, 24(4).

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Bioactive Compound Library Inhibitor Library Stem Cell Differentiation Compound Library Immunology/Inflammation Compound Library Apoptosis Compound Library HIF-1 Signaling Pathway Compound Library Kinase Inhibitor Library Anti-Aging Compound Library Bioactive Compounds Library Max

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Keywords

2-D08 144707-18-6 Tyrosine Kinase/Adaptors Ubiquitination E1/E2/E3 Enzyme TAM Receptor Ubiquitin ligase Axl Tyro3 E3 ligating enzyme Ubiquitin activating enzyme Inhibitor E1 activating enzyme inhibit 2-D-08 2 D08 2D08 E2 conjugating enzyme Mer Ubiquitin conjugating enzyme inhibitor

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