Powder: -20°C for 3 years | In solvent: -80°C for 2 years
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 189.00 | |
50 mg | In stock | $ 297.00 | |
100 mg | In stock | $ 538.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | 2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect. |
Targets&IC50 | Axl:0.49 nM |
In vitro | 2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474.[1] It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-β (Aβ) (1-42) aggregation and Aβ-induced toxicity in PC12 cells. It also has antioxidant properties[2]. |
Molecular Weight | 270.24 |
Formula | C15H10O5 |
CAS No. | 144707-18-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 150 mg/mL (555.06 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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2-D08 144707-18-6 Tyrosine Kinase/Adaptors Ubiquitination E1/E2/E3 Enzyme TAM Receptor Ubiquitin ligase Axl Tyro3 E3 ligating enzyme Ubiquitin activating enzyme Inhibitor E1 activating enzyme inhibit 2-D-08 2 D08 2D08 E2 conjugating enzyme Mer Ubiquitin conjugating enzyme inhibitor