Home Tools
Log in
Cart

Search Result

Search Results for " vhl-in-1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T79720 VHL-IN-1 HIF/HIF Prolyl-Hydroxylase
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for appli...
T7752 (S,R,S)-AHPC-Me VHL ligand 2,E3 ligase Ligand 1A Ligand for E3 Ligase
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a...
T13671 (S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride,E3 ligase Ligand 1 Others , Ligand for E3 Ligase
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell...
T17927 (S,R,S)-AHPC TFA VH032-NH2 TFA,VHL ligand 1 TFA Others , Ligand for E3 Ligase
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea...
T10359 AR antagonist 1 Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
T4207 (S,R,S)-AHPC hydrochloride VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride Others , Ligand for E3 Ligase
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
T17697 BRD7-IN-1 Epigenetic Reader Domain
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 through linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively [1].
T17920 (S,R,S)-AHPC-PEG1-N3 VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3 Others , Ligand for E3 Ligase
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC tec...
T5437 Gefitinib-based PROTAC 3 EGFR , PROTACs
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel...
T82928 Azido-PEG2-VHL PROTACs
Azido-PEG2-VHL is a multikinase degrader utilized in PROTACs (PROteolysis TArgeting Chimeras) synthesis [1].
T13671L (S,R,S)-AHPC-Me dihydrochloride VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) Others
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demon...
T77916 (S,R,S)-AHPC-Boc VH032-Boc
(S,R,S)-AHPC-Boc (VH032-Boc) serves as a ligand for the von Hippel-Lindau (VHL) protein recruitment in PROTAC technology [1].
T13958 VHL Ligand 8 Others
VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive p...
T18873 VHL Ligand-Linker Conjugates 17 Others
VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, ...
T18660 (S,R,S)-AHPC-amido-C5-acid Others
(S,R,S)-AHPC-amido-C5-acid is a chemical compound that contains a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It can be utilized in the design of XY028-133[1].
T18670 (S,R,S)-AHPC-Me-C5-COOH Others
(S,R,S)-AHPC-Me-C5-COOH is a synthetic E3 ligase ligand-linker conjugate consisting of a VHL ligand and a linker. It finds application in PROTAC DT2216[1].
T17696 BRD7-IN-1 free base Others
BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), interacts with a VHL ligand through a linker, constituting the PROTAC VZ185 (targeting BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively)[1].
T18667 (S,R,S)-AHPC-C5-COOH VH032-C5-COOH Others
(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized conjugate designed for E3 ligase ligand-linker applications, combining the VH032 VHL-based ligand with a linker for PROTAC development. VH-032 acts as a selective and...
T18669 (S,R,S)-AHPC-Me-C10-NH2 Others
(S,R,S)-AHPC-Me-C10-NH2 is a chemical compound consisting of a synthesized E3 ligase ligand-linker conjugate that incorporates both a VHL ligand and a linker. This compound, (S,R,S)-AHPC-Me-C10-NH2, finds application in ...
T17230 VH032-PEG3-acetylene Others
VH032-PEG3-acetylene is a synthesized conjugate compound consisting of a VH032-based VHL ligand and a linker, designed for use in PROTAC technology as an E3 ligase ligand-linker conjugate[1].

Compounds

VHL-IN-1
T79720
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
(S,R,S)-AHPC-Me
T7752
Synonym: VHL ligand 2,E3 ligase Ligand 1A
Target: Ligand for E3 Ligase
(S,R,S)-AHPC-Me hydrochloride
T13671
Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC TFA
T17927
Synonym: VH032-NH2 TFA,VHL ligand 1 TFA
Target: Others, Ligand for E3 Ligase
AR antagonist 1
T10359
Synonym:
Target: Androgen Receptor, Ligand for E3 Ligase, Ligands for Target Protein for PROTAC
(S,R,S)-AHPC hydrochloride
T4207
Synonym: VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride
Target: Others, Ligand for E3 Ligase
BRD7-IN-1
T17697
Synonym:
Target: Epigenetic Reader Domain
(S,R,S)-AHPC-PEG1-N3
T17920
Synonym: VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3
Target: Others, Ligand for E3 Ligase
Gefitinib-based PROTAC 3
T5437
Synonym:
Target: EGFR, PROTACs
Azido-PEG2-VHL
T82928
Synonym:
Target: PROTACs
(S,R,S)-AHPC-Me dihydrochloride
T13671L
Synonym: VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
Target: Others
(S,R,S)-AHPC-Boc
T77916
Synonym: VH032-Boc
Target:
VHL Ligand 8
T13958
Synonym:
Target: Others
VHL Ligand-Linker Conjugates 17
T18873
Synonym:
Target: Others
(S,R,S)-AHPC-amido-C5-acid
T18660
Synonym:
Target: Others
(S,R,S)-AHPC-Me-C5-COOH
T18670
Synonym:
Target: Others
BRD7-IN-1 free base
T17696
Synonym:
Target: Others
(S,R,S)-AHPC-C5-COOH
T18667
Synonym: VH032-C5-COOH
Target: Others
(S,R,S)-AHPC-Me-C10-NH2
T18669
Synonym:
Target: Others
VH032-PEG3-acetylene
T17230
Synonym:
Target: Others
1 2 3
TargetMol