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(S,R,S)-AHPC hydrochloride

Catalog No. T4207 CAS 1448189-80-7

Synonyms: VHL Ligand 1 hydrochloride, ULM-1, Protein degrader 1 hydrochloride

(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(S,R,S)-AHPC hydrochloride Chemical Structure

(S,R,S)-AHPC hydrochloride, CAS 1448189-80-7

Pack Size	Availability	Price/USD
50 mg	In stock	$ 48.00
100 mg	In stock	$ 72.00
500 mg	In stock	$ 247.00
1 g	In stock	$ 393.00

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Purity: 98.18%

Purity: 98.04%

Purity: 97.24%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).

In vitro

Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used

Synonyms	VHL Ligand 1 hydrochloride, ULM-1, Protein degrader 1 hydrochloride
Molecular Weight	467.03
Formula	C22H31ClN4O3S
CAS No.	1448189-80-7

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

Related Products

Related compounds with same targets

TL12-186 AR antagonist 1 (S,R,S)-AHPC-Me-C10-NH2 hydrochloride Thalidomide-NH-C4-NH-Boc VL285 Pomalidomide-PEG4-C2-NH2 E3 ligase Ligand 23 TD-165

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(S,R,S)-AHPC hydrochloride 1448189-80-7 Others PROTAC Ligand for E3 Ligase (S,R,S) AHPC hydrochloride VHL Ligand 1 Hydrochloride VH032-NH2 (S,R,S)AHPC hydrochloride inhibit (S,R,S)-AHPC VHL Ligand 1 hydrochloride VHL ligand 1 ULM-1 Ligands for E3 Ligase Protein degrader 1 Hydrochloride VHL ligand-1 ULM1 E3 ligase-recruiting Moiety VHL ligand1 ULM 1 Inhibitor AHPC Hydrochloride Protein degrader 1 hydrochloride inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.