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BRD7-IN-1

🥰Excellent
Catalog No. T17697Cas No. 2448414-48-8

BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively [1].

BRD7-IN-1
Other Forms of BRD7-IN-1:
BRD7-IN-1 free baseT176962305379-66-0
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BRD7-IN-1

🥰Excellent
Purity: 98.95%
Catalog No. T17697Cas No. 2448414-48-8
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively [1].
Pack SizePriceAvailabilityQuantity
1 mg$100In Stock
5 mg$247In Stock
10 mg$372In Stock
25 mg$668In Stock
50 mg$1,070In Stock
100 mg$1,480In Stock
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.95%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively [1].
Chemical Properties
Molecular Weight467.39
FormulaC22H28Cl2N4O3
Cas No.2448414-48-8
SmilesCl.Cl.COc1cc(cc(OC)c1CN1CCNCC1)-c1cn(C)c(=O)c2cnccc12
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (64.19 mM), Sonication is recommended.
H2O: 100 mg/mL (213.95 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (5.35 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.1395 mL10.6977 mL21.3954 mL106.9770 mL
5 mM0.4279 mL2.1395 mL4.2791 mL21.3954 mL
10 mM0.2140 mL1.0698 mL2.1395 mL10.6977 mL
20 mM0.1070 mL0.5349 mL1.0698 mL5.3489 mL
50 mM0.0428 mL0.2140 mL0.4279 mL2.1395 mL
H2O
1mg5mg10mg50mg
100 mM0.0214 mL0.1070 mL0.2140 mL1.0698 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitEpigeneticReaderDomainEpigenetic Reader DomainBRD9BRD7-IN-1BRD-7-IN-1BRD7IN1BRD7, BRD9BRD7 IN 1BRD7
Related Tags: buy BRD7-IN-1 | purchase BRD7-IN-1 | BRD7-IN-1 cost | order BRD7-IN-1 | BRD7-IN-1 chemical structure | BRD7-IN-1 formula | BRD7-IN-1 molecular weight
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