vdr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13292	VDR agonist 1		Others
	VDR agonist 1 (compound 28), a nonsteroidal Vitamin D receptor (VDR) agonist, demonstrates potent activity with a low IC 50 of 690 nM in MCF-7 cells. It inhibits cell cycle progression through upregulation of p21 and p27...		Others
T78944	VDR agonist 2
	VDR agonist 2 (compound 16i), a vitamin D receptor (VDR) agonist, effectively inhibits TGF-β1-induced hepatic stellate cell (HSC) activation, demonstrating notable anti-hepatic fibrosis efficacy both in vitro and in vivo...
TQ0200	Paricalcitol
	Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
T24166	Inecalcitol	TX 522,TX-522,TX522	Apoptosis
	Inecalcitol (TX 522) is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.		Apoptosis
T16015	Maxacalcitol	22-Oxacalcitriol	Others
	Maxacalcitol (22-Oxacalcitriol) is a ligand of VDR-like receptors and a non-serum calcium vitamin D3 analogue. Maxacalcitol inhibits parathyroid hormone (PTH) mRNA expression in vitro and in vivo.		Others
TQ0244	Calcipotriol monohydrate
	Calcipotriol monohydrate is an analog of Vitamin D3 with a high affinity for the vitamin D receptor. Calcipotriol monohydrate can be used for studies about psoriasis.
T14856	Calcipotriol	MC 903,Calcipotriene
	Calcipotriol (MC 903) is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor.
T1086	Vitamin D2	Calciferol,Ergocalciferol,Ercalciol	DNA/RNA Synthesis , Endogenous Metabolite
	Ergocalciferol (Vitamin D2 (Calciferol)) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder tumor promotion by sodium saccharin, and it in...		DNA/RNA Synthesis , Endogenous Metabolite
T6316	Calcitriol	Topitriol,Rocaltrol,Calcijex,RO215535,1,25-Dihydroxyvitamin D3	Endogenous Metabolite
	Calcitriol (1,25-Dihydroxyvitamin D3) is a metabolite of vitamin D and a vitamin D receptor (VDR) agonist (IC50=0.4 nM). Calcitriol increases intestinal absorption of calcium and phosphorus, and increases bone resorption...		Endogenous Metabolite
T1135	Vitamin D3	Cholecalciferol,Colecalciferol	Endogenous Metabolite
	Vitamin D3 (Cholecalciferol) , a naturally occurring form of vitamin D, activates an H305F/H397Y mutant vitamin D receptor (VDR).		Endogenous Metabolite
T6430L	Calcifediol monohydrate	25-hydroxy Vitamin D3 monohydrate	Endogenous Metabolite
	Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), the main circulating metabolite of vitamin D3, is a potent VDR inhibitor.		Endogenous Metabolite
T6430	Calcifediol	U 32070E,25-hydroxy Vitamin D3,RO 8-8892	Endogenous Metabolite
	Calcifediol (U 32070E)(Ki of 3.9 μM), a major circulating metabolite of vitamin D3, works as a competitive inhibitor. It (ED50=2 nM)also inhibits PTH secretion and mRNA.		Endogenous Metabolite
T6112	Doxercalciferol	TSA 840,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2	Others
	Doxercalciferol (TSA 840) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.		Others
T6374	Alfacalcidol	Bondiol,Etalpha,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol	Others
	Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.		Others
T13404	ZK168281		Others
	ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure antagonist of VDR (Kd of 0.1 nM). ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.		Others
T11952	Maxacalcitol-D6		Others
	Maxacalcitol-D6 is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol).		Others
T24675	PS121912	PS-121912,PS 121912
	PS121912 is a potent and selective inhibitor of VDR-coactivator.
T17292	ZK159222		Others
	ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.		Others
T75123	Maxacalcitol-d
	Maxacalcitol-d6 is a deuterated variant of Maxacalcitol (22-Oxacalcitriol), serving as a non-calcemic analog of vitamin D3 and a ligand for VDR and VDR-like receptors.
T69676	LG190155
	LG190155 is a moderately potent VDR agonist. Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types.