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Doxercalciferol

Catalog No. T6112 CAS 54573-75-0

Synonyms: TSA 840, Hectorol, 1.alpha.-Hydroxyvitamin D2, 1α-hydroxyvitamin D2

Doxercalciferol (TSA 840) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.

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Doxercalciferol, CAS 54573-75-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 52.00
5 mg	In stock	$ 81.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 288.00
50 mg	In stock	$ 540.00
100 mg	In stock	$ 779.00
500 mg	In stock	$ 1,620.00
1 mL * 10 mM (in DMSO)	In stock	$ 81.00

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Purity: 99.69%

Purity: 98.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Doxercalciferol (TSA 840) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.

In vivo

Doxercalciferol (100 or 300 pg/g b.w.) normalizes serum calcium and parathyroid hormone (PTH) levels in nephrectomy treated mice. Doxercalciferol (300 pg/g b.w.) significantly reduces osteitis fibrosa in nephrectomy treated mice. [1] Doxercalciferol results in significant decrease in cardiac hypertrophy and improves cardiac function in rats fed a high salt (HS) diet. Doxercalciferol treatment leads to a significant decrease in plasma brain natriuretic peptide (BNP) level and tissue atrial natriuretic factor (ANF) mRNA level in rats fed a high salt (HS) diet. Doxercalciferol also significantly reduces the level of protein kinase C-α (PKCα) suggesting that PKC-mediated cardiac hypertrophy may be associated with vitamin D deficiency. [2] Doxercalciferol decreases proteinuria, podocyte injury, mesangial expansion, and extracellular matrix protein accumulation in Diet-induced obesity (DIO) mice. Doxercalciferol also decreases macrophage infiltration, oxidative stress, proinflammatory cytokines, and profibrotic growth factors in DIO mice. Doxercalciferol also prevents the activation of the renin-angiotensin-aldosterone system including the angiotensin II type 1 receptor and the mineralocorticoid receptor in DIO mice. [3] Doxercalciferol combined with Losartan most effectively prevents albuminuria, restored glomerular filtration barrier structure, and dramatically reduces glomerulosclerosis in a dose-dependent manner in mice. Doxercalciferol combined with Losartan virtually prevents morphological and molecular changes in diabetic kidneys of mice. [4]

Synonyms	TSA 840, Hectorol, 1.alpha.-Hydroxyvitamin D2, 1α-hydroxyvitamin D2
Molecular Weight	412.65
Formula	C28H44O2
CAS No.	54573-75-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 20.6 mg/mL (50 mM)

DMSO: 4.1 mg/mL (10 mM)

References and Literature

1. St-Arnaud R, et al. Nephron Exp Nephrol,2011, 119(3), e67-74. 2. Choi JH, et al. J Card Fail,2011, 17(12), 1051-1058. 3. Wang XX, et al. Am J Physiol Renal Physiol. 2011 Mar;300(3):F801-10. 4. Zhang Y, et al. Am J Physiol Renal Physiol,2009, 297(3), F791-801.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Ferroptosis Compound Library Approved Drug Library Bioactive Compound Library Anti-Cancer Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Doxercalciferol 54573-75-0 Others TSA840 1a-hydroxyvitamin D2 Vitamin D receptor 1alpha-hydroxyvitamin D2 inhibit TSA 840 Inhibitor Hectorol Vitamin D TSA-840 1.alpha.-Hydroxyvitamin D2 VD/VDR 1α-hydroxyvitamin D2 inhibitor

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