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Metabolism Vitamin Paricalcitol

Paricalcitol

Catalog No. TQ0200   CAS 131918-61-1

Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.

Paricalcitol, CAS 131918-61-1
Pack Size Availability Price/USD Quantity
1 mg In stock 165.00
5 mg In stock 650.00
10 mg In stock 1135.00
25 mg In stock 1816.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
Targets&IC50
In vivo Paricalcitol (300 ng/kg/day) significantly decreases Tau and prevents LV dysfunction in mice. It reduces mRNA expression of ANP, fibronectin and collagen III in the TAC-pari mice [2].
Animal Research
After TAC or sham surgery, a subset of the mice is treated with paricalcitol which activates the VDR, at a final dose of 300 ng/kg/day. Paricalcitol is dissolved in a 95% propylene glycol and 5% ethyl alcohol solution. Mice were intraperitoneally injected with paricalcitol (or vehicle only) three times per week on Monday, Wednesday, and Friday for five consecutive weeks. An established anti-hypertrophic and anti-fibrotic treatment, namely the angiotensin II receptor blocker (ARB) losartan is also included. Previous experiments have shown it is feasible and efficacious to dissolve losartan in the drinking water at a concentration of 30 mg/kg/day; mice are treated for five consecutive weeks. So, in total eight groups are studied. Sham (n=10), TAC (n=10), Sham + losartan (Sham-los, n=10), TAC + losartan (TAC-los, n=10), Sham + paricalcitol (Sham-pari, n=10), TAC + paricalcitol (TAC-pari, n=10), Sham + paricalcitol + losartan (Sham-combi, n=10) and TAC + paricalcitol + losartan (TAC-combi, n=10) [2].
Molecular Weight 416.64
Formula C27H44O3
CAS No. 131918-61-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 95 mg/mL (228.02 mM), Need ultrasonic

Ethanol: 12 mg/mL (38.8 mM), Need ultrasonic

Water: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Martinez-Moreno JM, et al. In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation. Am J Physiol Renal Physiol. 2012 Aug 8. 2. Meems LM, et al. The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289.

Related Products

Related compounds with same targets
Paricalcitol Beta-Carotene Calcipotriol Ercalcitriol Coumetarol Acenocoumarol Calcipotriol monohydrate Menatetrenone

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