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Calcipotriol

Name: Calcipotriol
Brand: TargetMol
SKU: T14856
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14856Cas No. 112965-21-6

Alias MC 903, Calcipotriene

Calcipotriol (MC 903) is a synthetic vitamin D3 analogue with high affinity for the vitamin D receptor.

Calcipotriol

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Purity: 99.07%

Catalog No. T14856Alias MC 903, CalcipotrieneCas No. 112965-21-6

Calcipotriol (MC 903) is a synthetic vitamin D3 analogue with high affinity for the vitamin D receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$52	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$133	In Stock	-
50 mg	$237	In Stock	-
100 mg	$432	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.07%

Color:White to Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Calcipotriol (MC 903) is a synthetic vitamin D3 analogue with high affinity for the vitamin D receptor.
Targets&IC50	GL261 cells:69.65 µM, HEK293/MRP1 cells:6.0 ± 1.8 μM
In vitro	METHODS: HaCaT cells were treated with Calcipotriol (10⁻9 M, 10⁻⁷ M, and 10⁻⁵ M), and Western Blot was used to detect the expression levels of target proteins. RESULTS: IFN-γinduced K17 protein expression in HaCaT cells, and Calcipotriol dose-dependently inhibited this expression. 10⁻⁷ M and 10⁻⁵ M Calcipotriol inhibited K17 protein expression by 58.10% and 70.68%, respectively. [1] METHODS: AsPC-1 cells were treated with 100 nM Calcipotriol, and Western Blot was used to detect the expression levels of target proteins. RESULTS: LRP6 protein levels were significantly decreased after Calcipotriol treatment. [2]
In vivo	METHODS: To study the antitumor activity of Diclofenac, Calcipotriol and Difluoromethylornithine, Diclofenac (100 μg/week), Calcipotriol (0.166 μg/week), calcipotriol (0.166 μg/week), The Difluoromethylornithine (463.3 μg/week) mixture was applied to the dorsal surface of mice once a day, five days a week for 17 weeks. RESULTS: Compared with the placebo group, the Diclofenac plus Calcipotriol group and Diclofenac plus DFMO plus Calcipotriol group showed significantly less weight gain. [3]
Disease Modeling Protocol	Atopic Dermatitis (AD) Inflammation Model Modeling Mechanism： Calcipotriol, as a vitamin D₃ analogue, activates skin keratinocytes after topical application, induces the release of cytokines such as thymic stromal lymphopoietin (TSLP), drives a type 2 immune response (Th2 cell and ILC2 activation), promotes the expression of Th2 cytokines such as IL-4 and IL-13, and triggers epidermal edema, dermal immune cell infiltration, and the formation of AD-like inflammation. This process does not depend on the IL-33/ST2 signaling pathway and may involve compensatory effects from factors such as TSLP and IL-25. Related Products： Calcipotriol (T14856) Modeling Method： Experimental Subject：Mice · C57BL/6JBomTac background (including IL-33⁻/⁻, ST2⁻/⁻, IL-33⁻/⁻ST2⁻/⁻ double knockout and wild-type strains) · 8–10 weeks of age Dosage and Administration Route：2 nmol calcipotriol (dissolved in 20 μl ethanol), Topically applied daily to both ears (front and back surfaces), Control group received equivalent ethanol application Dosing Frequency and Duration Model：Once daily for 8 consecutive days Validation： Phenotypic features: Both ears showed erythema, dryness, and thickening, with a significant increase in ear thickness, accompanied by itchy scratching behavior. There were no significant differences in phenotype among different genotypes. Histology: Epidermal spongiosis was observed, and mononuclear cells and granulocytes were infiltrated in the dermis and epidermis. The density of CD45⁺ immune cells and CD3⁺ T cells infiltrated was not different among different genotypes. Molecular markers: The expression of IL-4 and IL-13 mRNA in skin tissue was significantly increased, while the absence of IL-33/ST2 did not affect their expression levels. Precautions： After the experiment, mice were euthanized with CO₂, and ear skin tissue was collected. Part of the tissue was fixed in 4% paraformaldehyde (for histological examination), and the rest was preserved in RNAlater (for gene expression detection). References：Pietka W,et,al. Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice. Sci Rep. 2020 Apr 15;10(1):6451.
Synonyms	MC 903, Calcipotriene

Chemical Properties

Molecular Weight	412.6
Formula	C₂₇H₄₀O₃
Cas No.	112965-21-6
Smiles	C[C@H](\C=C\[C@@H](O)C1CC1)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Relative Density.	1.12g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 122.5 mg/mL (296.9 mM), Sonication is recommended.

Ethanol: 50 mg/mL (121.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4237 mL	12.1183 mL	24.2365 mL	121.1827 mL
5 mM	0.4847 mL	2.4237 mL	4.8473 mL	24.2365 mL
10 mM	0.2424 mL	1.2118 mL	2.4237 mL	12.1183 mL
20 mM	0.1212 mL	0.6059 mL	1.2118 mL	6.0591 mL
50 mM	0.0485 mL	0.2424 mL	0.4847 mL	2.4237 mL
100 mM	0.0242 mL	0.1212 mL	0.2424 mL	1.2118 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc