Metabolism Vitamin Calcipotriol


Catalog No. T14856   CAS 112965-21-6
Synonyms: MC 903, Calcipotriene

Calcipotriol is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor.

Calcipotriol, CAS 112965-21-6
Pack Size Availability Price/USD Quantity
5 mg In stock 59.00
10 mg In stock 80.00
50 mg In stock 264.00
100 mg In stock 480.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Calcipotriol is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor.
Targets&IC50 Vitamin D receptor,  
In vitro Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM), when NHEK cells are not stimulated with IL-17A or IL-22. The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20, and 40 nM in a dose-dependent manner [1]. Treatment of natural killer (NK) cells with drugs modulate their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)2D3, Calcipotriol or FTY720 for 4 h. All three concentrations of Calcipotriol, 1,25(OH)2D3, and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation [2].
In vivo Compare with placebo, the weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002). Survival is equally distributed between the groups. One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived [3].
Synonyms MC 903 , Calcipotriene
Purity 99.07%
Molecular Weight 412.6
Formula C27H40O3
CAS No. 112965-21-6


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 100 mg/mL (242.37 mM)

Ethanol: 50 mg/mL (121.18 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Sakabe JI, et al. Calcipotriol Increases hCAP18 mRNA Expression but Inhibits Extracellular LL37 Peptide Production in IL-17/IL-22-stimulated Normal Human Epidermal Keratinocytes. Acta Derm Venereol. 2014 Sep;94(5):512-6. 2. Al-Jaderi Z, et al. Effects of vitamin D3, calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells. Toxins (Basel). 2013 Oct 28;5(11):1932-47. 3. Pommergaard HC, et al. Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. Anticancer Res. 2013 Aug;33(8):3033-9. 4. Reinhard Bredehorst, et al. Induction of Antigen-Specific Tolerance by Peripheral Phagocytosis. US 20150283231 A1. 5. Kaur A, et al. Nanoemulsion loaded gel for topical co-delivery of clobitasol propionate and calcipotriol in psoriasis. Nanomedicine. 2017 May;13(4):1473-1482.

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Paricalcitol Beta-Carotene Calcipotriol Ercalcitriol Coumetarol Acenocoumarol Calcipotriol monohydrate Menatetrenone

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