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Cat No. | Product Name | Synonyms | Targets |
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T9921 | Infliximab | TNF | |
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis. | |||
T61111 | UCB-5307 | TNF | |
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pas... | |||
T38361 | GSK717 | IL Receptor , NOD | |
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio... | |||
T71807 | UCB-6786 | ||
UCB-6786 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control protein... | |||
T68954 | UCB-6876 | ||
UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control protein... | |||
T80561 | Atrosab | ||
Atrosab, a humanized IgG1 anti-TNFR1 antibody, exhibits antagonistic properties by inhibiting TNF-induced apoptosis and reducing the production of IL-6 and IL-8. It is utilized for research on inflammatory diseases [1]. | |||
T27687 | JNJ525 | JNJ 525,JNJ-525 | |
JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of co... | |||
T36097 | TNF-α-IN-2 | ||
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in... | |||
T36486 | Benpyrine | ||
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten... | |||
T38263 | TBK1/IKKε-IN-4 | TBK1/IKKε-IN-4 | |
TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01459 | TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1. | |||
TMPY-02535 | TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118. | |||
TMPY-05475 | TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P19438-1. | |||
TMPK-00564 | TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of... | |||
TMPY-01639 | TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118. | |||
TMPY-03028 | TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is P22934. | |||
TMPY-03538 | TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.3 kDa and the accession number is P22934. | |||
TMPJ-00280 | TNF R1 Protein, Mouse, Recombinant | Mouse | E. coli |
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate t... | |||
TMPY-01166 | TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P20333-1. | |||
TMPY-03101 | TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is XP_005544817.1&NP_001253134.1... | |||
TMPY-01697 | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119. | |||
TMPY-06600 | TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.39 kDa and the accession number is NP_001057.1. | |||
TMPY-03588 | TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (hFc) | Cynomolgus,Rhesus | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is XP_005544817.1&NP_001253134.1... | |||
TMPY-01696 | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is P25119. | |||
TMPK-01382 | TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.... | |||
TMPY-00934 | TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 53 kDa and the accession number is P20333-1. | |||
TMPY-05814 | TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is P20333-1. | |||
TMPY-03881 | TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His) | Human | HEK293 Cells |
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is P20333-2. | |||
TMPY-02153 | TNF beta Protein, Human, Recombinant | Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lympho... | |||
TMPK-00745 | PGLYRP1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he... | |||
TMPK-00749 | PGLYRP1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he... | |||
TMPH-01620 | TNF beta Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a w... | |||
TMPH-02770 | TNF beta Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a w... | |||
TMPH-02876 | RIPK1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun... |