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Search Result

Search Results for " trpv1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T61788 TRPV1 antagonist 3
TRPV1 antagonist 3 (Compound 7q) is a highly potent antagonist of the TRPV1 receptor with an IC50 of 2.66 nM against capsaicin. It exhibits selectivity towards its mode of action and is orally bioavailable (with a bioava...
T74742 TRPV1 activator-2
TRPV1 activator-2 (Compound 9), a capsaicin head analog, engages in targeted interactions with channel residues at the lipid-water interface [1].
T83701 TRPV1-Tat TFA Transient Receptor Potential Vanilloid 1-Tat,736-745-Tat
TRPV1-Tat, a peptide antagonist targeting transient receptor potential vanilloid 1 (TRPV1), is composed of amino acids 736-745 derived from TRPV1's A-kinase anchor protein (AKAP)-binding domain, combined with the HIV Tat...
T74741 TRPV1 activator-1
TRPV1 Activator-1 (Compound 8), a capsaicin analog featuring a modified neck structure, specifically interacts with the T551 residue [1].
T22360 MDR-652 TRP/TRPV Channel
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ...
T23322 SB 452533 TRP/TRPV Channel
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
T15758 Linopirdine DuP 996 Potassium Channel , TRP/TRPV Channel
Linopirdine (DuP 996) is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is a cognitive enhancer. It acts by stimulating rel...
T7526 JNJ-17203212 TRP/TRPV Channel
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
T6379 AMG 517 AMG517,AMG-517 TRP/TRPV Channel
AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.
T7189 AMG9810 TRP/TRPV Channel
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).
T8562 A 425619 1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA TRP/TRPV Channel
A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonist
T6977 SB-366791 SB366791 TRP/TRPV Channel
SB-366791 is a new and selective cinnamide TRPV1 antagonist.
T6660 SB-705498 TRP/TRPV Channel
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
TN2429 Capsiate Antioxidant , TRP/TRPV Channel
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.
T1062 Capsaicin Qutenza,8-Methyl-N-vanillyl-trans-6-nonenamide,Vanilloid,(E)-Capsaicin,Zostrix Apoptosis , TRP/TRPV Channel , Autophagy
Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.
T8307 Hydroxy-α-sanshool Hydroxy-​α-​sanshool Endogenous Metabolite , TRP/TRPV Channel
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
T12306 OMDM-5 Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
T12307 OMDM-6 Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel
OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM.
T29522 ABT 102 ABT102,CHEMBL398338,ABT-102 TRP/TRPV Channel
ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.
T29522L (S)-ABT 102 TRP/TRPV Channel
N-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea is a potent TRPV1 antagonist, blocking activation of TRPV1 by capsaicin with the IC50 of 123 nM.
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