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Capsiate

Catalog No. TN2429 CAS 205687-01-0

Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.

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Capsiate, CAS 205687-01-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 189.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 643.00

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Purity: 96.24%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.
Targets&IC50	TRPV1:290 nM(EC50)
In vitro	Capsiate evokes current responses in HEK293 cells expressing TRPV1[3]. Capsiate (5 to 25 µM) inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, human umbilical vein endothelial cells (HUVECs).[1]
In vivo	Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice.[3] Topical application of Capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.[3] Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.[4]

Molecular Weight	306.4
Formula	C18H26O4
CAS No.	205687-01-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (293.7 mM), Sonication is recommended.

References and Literature

1. Pyun BJ, et al. Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res. 2008;68(1):227-235. 2. Iida T, et al. TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology. 2003;44(7):958-967. 3. Lee, et al. Capsiate Inhibits DNFB-Induced Atopic Dermatitis in NC/Nga Mice through Mast Cell and CD4+ T-Cell Inactivation. J Invest Dermatol. 2015;135(8):1977-1985. 4. Haramizu S, et al. Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice. Biomed Res. 2011;32(4):279-28

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Immunology/Inflammation Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Capsiate 205687-01-0 Membrane transporter/Ion channel oxidation-reduction TRP/TRPV Channel Antioxidant inhibitor inhibit

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