Search Result

Search Results for " tnfr1 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9921	Infliximab		TNF
	Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.		TNF
T61111	UCB-5307		TNF
	UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pas...		TNF
T38361	GSK717		IL Receptor , NOD
	GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio...		IL Receptor , NOD
T71807	UCB-6786
	UCB-6786 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control protein...
T68954	UCB-6876
	UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control protein...
T80561	Atrosab
	Atrosab, a humanized IgG1 anti-TNFR1 antibody, exhibits antagonistic properties by inhibiting TNF-induced apoptosis and reducing the production of IL-6 and IL-8. It is utilized for research on inflammatory diseases [1].
T27687	JNJ525	JNJ 525,JNJ-525
	JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of co...
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in...
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten...
T38263	TBK1/IKKε-IN-4	TBK1/IKKε-IN-4
	TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced ...

Compounds

Target: IL Receptor, NOD

Synonym: JNJ 525,JNJ-525

Synonym: TBK1/IKKε-IN-4

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01459	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1.
TMPY-02535	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118.
TMPY-05475	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P19438-1.
TMPK-00564	TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of...
TMPY-01639	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118.
TMPY-03028	TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is P22934.
TMPY-03538	TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.3 kDa and the accession number is P22934.
TMPJ-00280	TNF R1 Protein, Mouse, Recombinant	Mouse	E. coli
	Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate t...
TMPY-03101	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is XP_005544817.1&NP_001253134.1...
TMPY-01166	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P20333-1.
TMPY-01697	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119.
TMPY-06600	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.39 kDa and the accession number is NP_001057.1.
TMPY-03588	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (hFc)	Cynomolgus,Rhesus	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is XP_005544817.1&NP_001253134.1...
TMPY-01696	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is P25119.
TMPK-01382	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa....
TMPY-00934	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 53 kDa and the accession number is P20333-1.
TMPY-05814	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is P20333-1.
TMPY-03881	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His)	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is P20333-2.
TMPY-02153	TNF beta Protein, Human, Recombinant	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lympho...
TMPK-00745	PGLYRP1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPK-00749	PGLYRP1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPH-01620	TNF beta Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a w...
TMPH-02770	TNF beta Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a w...
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...