sglt2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9590	T-1095		SGLT , transporter
	T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).		SGLT , transporter
T2385	Ipragliflozin	ASP1941	SGLT
	Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.		SGLT
T67849	O-Desethyl Dapagliflozin	Empagliflozin-4	SGLT
	O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.		SGLT
T5016	Tofogliflozin (hydrate)	Tofogliflozin hydrate,CSG-452 hydrate	SGLT , Reactive Oxygen Species , ROS
	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).		SGLT , Reactive Oxygen Species , ROS
T34286	Remogliflozin etabonate	GSK189075,GSK 189075,GSK-189075A,GSK189075A,GSK-189075,GSK 189075A	SGLT
	Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively.		SGLT
T1782	Canagliflozin	JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754	SGLT
	Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.		SGLT
T4999	Ertugliflozin	MK-8835,PF-04971729	SGLT
	PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).		SGLT
T2389	Dapagliflozin	BMS-512148	SGLT , HIF
	Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.		SGLT , HIF
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate)	BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate	SGLT
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre...		SGLT
T3547	Sotagliflozin	LX-4211,LP-802034	SGLT
	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.		SGLT
T7217	Bexagliflozin	THR-1442,EGT1442,EGT0001442	SGLT
	Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively		SGLT
T68174	Sergliflozin A		SGLT
	Sergliflozin A is a selective SGLT2 inhibitor that induces diabetes in a dose-dependent manner. It reduces hyperglycemia.		SGLT
T16083	Mizagliflozin	GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT
	Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca...		SGLT
T15656	KGA-2727		SGLT
	KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA...		SGLT
T28757	Sergliflozin etabonate	GW-869682,GW-869682X,KGT-1251,GW869682X,GW869682,KGT1251	SGLT
	Sergliflozin etabonate (KGT-1251) is an inhibitor of SGLT2 and can be used in studies about type 2 diabetes and obesity.		SGLT
T1782L	Canagliflozin hemihydrate	JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754	SGLT
	Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reab...		SGLT
T15244	Ertugliflozin L-pyroglutamic acid	PF-04971729 L-pyroglutamic acid	Others , SGLT
	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatmen...		Others , SGLT
T1766	Empagliflozin	BI 10773	SGLT
	Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes.		SGLT
T11667	Ipragliflozin (L-Proline)	Ipragliflozin L-Proline	Others
	Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.		Others
T15505	HSK0935	HSK 0935,HSK-0935	SGLT
	HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.		SGLT