Powder: -20°C for 3 years
In solvent: -80°C for 2 years
HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
Description | HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities. |
Targets&IC50 | SGLT2:1.3 nM |
In vitro | HSK0935 shows excellent hSGLT2 inhibition of 1.3 nM. HSK0935 displays a high hSGLT1/hSGLT2 selectivity of 843-fold[1]. |
In vivo | HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs. HSK0935 treatment (1, 3, and 10 mg/kg) displays robust urinary glucose excretion in Sprague?Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys[1]. |
Synonyms | HSK-0935, HSK 0935 |
Molecular Weight | 436.89 |
Formula | C22H25ClO7 |
CAS No. | 1638851-44-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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HSK0935 1638851-44-1 GPCR/G Protein SGLT HSK-0935 HSK 0935 Inhibitor inhibitor inhibit