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HSK0935

Catalog No. T15505 CAS 1638851-44-1

Synonyms: HSK-0935, HSK 0935

HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.

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HSK0935, CAS 1638851-44-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
Targets&IC50	SGLT2:1.3 nM
In vitro	HSK0935 shows excellent hSGLT2 inhibition of 1.3 nM. HSK0935 displays a high hSGLT1/hSGLT2 selectivity of 843-fold[1].
In vivo	HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs. HSK0935 treatment (1, 3, and 10 mg/kg) displays robust urinary glucose excretion in Sprague?Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys[1].

Synonyms	HSK-0935, HSK 0935
Molecular Weight	436.89
Formula	C22H25ClO7
CAS No.	1638851-44-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Li Y, et al. Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes. J Med Chem. 2017 May 25;60(10):4173-4184.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HSK0935 1638851-44-1 GPCR/G Protein SGLT HSK-0935 HSK 0935 Inhibitor inhibitor inhibit

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