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Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T62189	SRANKL-IN-1
	sRANKL-IN-1 (compound S3) is an inhibitor of sRANKL (soluble RANKL). sRANKL-IN-1 is a strong inhibitor of osteoclasts (IC50: 0.096 μM, Kd: 34.80 μM). sRANKL-IN-1 can be used in the study of osteoporosis.
T25859	Necrostatin-7	Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7	Apoptosis
	Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts.		Apoptosis
T9917	Denosumab		RANKL/RANK
	Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand		RANKL/RANK
T38129	Leukotriene F4	LTF4
	LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contrac...
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact sit...
T70049	Ro 04-5595 free base
	Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific bindi...
T80195	Garvicin KS, GakB
	Garvicin KS (GarKS) is a bacteriocin comprising a 34-amino-acid peptide, GakB, along with two additional peptides, GakA and GakC. GakB specifically impairs fibroblast viability and proliferation. When combined with GakA,...

Compounds

Synonym: Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7

Target: RANKL/RANK

Cat No.	Product Name	Synonyms	Targets
T5528	Cyanidin Chloride		Antioxidant
	Cyanidin Chloride, the main phenolic antioxidant in the grape (Vitis vinifera), in particular in the liposomal forms, could be used for treatment of diabetes mellitus complications.		Antioxidant
TN2586	11-Hydroxyrankinidine		Others
	11-Hydroxyrankinidine is a natural product for research related to life sciences. The catalog number is TN2586 and the CAS number is 122590-03-8.		Others
T34259	Rankinidine
	Rankinidine, as an oxindole alkaloid, is isolated from Gelsemium rankinii.
T5720	Boldine	1,10-Dimethoxy-2,9-dihydroxyaporphine,ex Peumus boldus	RANKL/RANK
	Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natual product .Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities.		RANKL/RANK

Natural Products

11-Hydroxyrankinidine

Synonym: 1,10-Dimethoxy-2,9-dihydroxyaporphine,ex Peumus boldus

Target: RANKL/RANK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04142	RANK/TNFRSF11A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
TMPK-00723	RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...
TMPY-04157	RANK/TNFRSF11A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.5 kDa and the accession number is Q9Y6Q6-3.
TMPY-05514	RANK/TNFRSF11A Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9Y6Q6-3.
TMPK-00351	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)	Human	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i...
TMPY-03026	RANK/TNFRSF11A Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	RANK/TNFRSF11A Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.1 kDa and the accession number is F1M8Z6.
TMPJ-00349	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)	Human	HEK293 Cells
	Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANK...
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acid...
TMPY-02851	RANK/TNFRSF11A Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	RANK/TNFRSF11A Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.5 kDa and the accession number is F1M8Z6.
TMPJ-00607	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
TMPY-03674	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 52.4 kDa and the accession number is AAC51762.1.
TMPY-02726	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is AAC40113.1.
TMPY-03364	RANKL/TNFSF11/CD254 Protein, Human, Recombinant	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.5 kDa and the accession number is AAC51762.1.
TMPK-00717	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)	Human	HEK293 Cells
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPK-00591	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His)	Mouse	HEK293 Cells
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPK-00716	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244)	Human	HEK293 Cells
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPJ-01472	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1.
TMPY-06561	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc)	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 46.18 kDa and the accession number is AAC51762.1.
TMPY-00537	RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is G7PW41.
TMPY-03527	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.9 kDa and the accession number is O14788-2.
TMPY-01471	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is AAC51762.1.
TMPJ-01466	Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)	Human	HEK293 Cells
	TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits ...
TMPH-01294	EDNRA Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
TMPH-02147	TACR1 Protein, Human, Recombinant (GST)	Human	E. coli
	This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor ...
TMPH-03749	CYSLTR1 Protein, Human, Recombinant (His)	Human	E. coli
	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and...
TMPH-01767	NPY2R Protein, Human, Recombinant (His)	Human	E. coli
	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY a...
TMPJ-00253	OPG Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulat...
TMPH-02264	TNFSF11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator...
TMPJ-00225	Siglec-15 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai...