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Boldine

Catalog No. T5720 CAS 476-70-0

Synonyms: 1,10-Dimethoxy-2,9-dihydroxyaporphine, ex Peumus boldus

Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natual product .Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Boldine, CAS 476-70-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 41.00
25 mg	In stock	$ 74.00
50 mg	In stock	$ 124.00
100 mg	In stock	$ 197.00
200 mg	In stock	$ 297.00

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Purity: 98.53%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natual product .Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities.
In vitro	Boldine was able to reduce cell viability and cell proliferation in T24 cells.?In addition, boldine arrests the cell cycle at G2/M-phase and cause cell death by apoptosis.?Boldine-induced inhibition of cell growth and cell cycle arrest appears to be linked to inactivation of extracellular signal-regulated kinase protein (ERK).?Additionally, the efficacy of boldine in apoptosis-induced in T24 cells is correlated with modulation of AKT (inactivation) and glycogen synthase kinase-3β (GSK-3β) (activation) proteins[1].
In vivo	Boldine reduced oxidative stress and improved endothelium-dependent relaxation in aortas of diabetic mice largely through inhibiting ROS overproduction associated with Ang II-mediated BMP4-dependent mechanisms[2].
Cell Research	Sulforhodamine B assay, Tetrazolium reduction assay, Flow Cytometry Analysis, Ecto-5'-nucleotidase activity and Western blot assay were performed[1].
Animal Research	Vascular reactivity was studied in mouse aortas from db/db diabetic and normal mice.?Reactive oxygen species (ROS) production, angiotensin AT1 receptor localization and protein expression of oxidative stress markers in the vascular wall were evaluated by dihydroethidium fluorescence, lucigenin enhanced-chemiluminescence, immunohistochemistry and Western blot respectively.?Primary cultures of mouse aortic endothelial cells, exposed to high concentrations of glucose (30?mmol L(-1) ) were also used[2].
Source	Natural Products > Lauraceae > Litsea

Synonyms	1,10-Dimethoxy-2,9-dihydroxyaporphine, ex Peumus boldus
Molecular Weight	327.37
Formula	C19H21NO4
CAS No.	476-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (198.55 mM)

References and Literature

1. Gerhardt, Daniéli, Bertola G , Dietrich, Fabrícia, et al. Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β[J]. Urologic Oncology: Seminars and Original Investigations, 2014, 32(1):36.e1-36.e9. 2. Lau Y S , Tian X Y , Mustafa M R , et al. Boldine improves endothelial function in diabetic\r, db/db\r, mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade[J]. British Journal of Pharmacology, 2013, 170(6):1190-1198.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Anti-Breast Cancer Compound Library Anti-Aging Compound Library Anti-Liver Cancer Compound Library Selected Plant-Sourced Compound Library Natural Product Library NF-κB Signaling Compound Library Anti-Gastroenteritis Natural Product Library

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Keywords

Boldine 476-70-0 NF-Κb RANKL/RANK 1,10-Dimethoxy-2,9-dihydroxyaporphine inhibit Inhibitor ex Peumus boldus inhibitor

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