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Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T62189	SRANKL-IN-1
	sRANKL-IN-1 (compound S3) is an inhibitor of sRANKL (soluble RANKL). sRANKL-IN-1 is a strong inhibitor of osteoclasts (IC50: 0.096 μM, Kd: 34.80 μM). sRANKL-IN-1 can be used in the study of osteoporosis.
T25859	Necrostatin-7	Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7	Apoptosis
	Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts.		Apoptosis
T9917	Denosumab		RANKL/RANK
	Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand		RANKL/RANK
T38129	Leukotriene F4	LTF4
	LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contrac...
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact sit...
T70049	Ro 04-5595 free base
	Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific bindi...
T80195	Garvicin KS, GakB
	Garvicin KS (GarKS) is a bacteriocin comprising a 34-amino-acid peptide, GakB, along with two additional peptides, GakA and GakC. GakB specifically impairs fibroblast viability and proliferation. When combined with GakA,...

Compounds

Synonym: Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7

Target: RANKL/RANK

Cat No.	Product Name	Synonyms	Targets
T5528	Cyanidin Chloride		Antioxidant
	Cyanidin Chloride, the main phenolic antioxidant in the grape (Vitis vinifera), in particular in the liposomal forms, could be used for treatment of diabetes mellitus complications.		Antioxidant
TN2586	11-Hydroxyrankinidine		Others
	11-Hydroxyrankinidine is a natural product for research related to life sciences. The catalog number is TN2586 and the CAS number is 122590-03-8.		Others
T34259	Rankinidine
	Rankinidine, as an oxindole alkaloid, is isolated from Gelsemium rankinii.
T5720	Boldine	1,10-Dimethoxy-2,9-dihydroxyaporphine,ex Peumus boldus	RANKL/RANK
	Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natual product .Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities.		RANKL/RANK

Natural Products

11-Hydroxyrankinidine

Synonym: 1,10-Dimethoxy-2,9-dihydroxyaporphine,ex Peumus boldus

Target: RANKL/RANK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04142	RANK/TNFRSF11A Protein, Human, Recombinant (hFc)	Human	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPK-00723	RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...
TMPY-04157	RANK/TNFRSF11A Protein, Human, Recombinant (His)	Human	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPY-05514	RANK/TNFRSF11A Protein, Human, Recombinant (mFc)	Human	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPK-00351	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)	Human	HEK293
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i...
TMPY-03026	RANK/TNFRSF11A Protein, Rat, Recombinant (hFc)	Rat	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPJ-00349	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)	Human	Human Cells
	Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANK...
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acid...
TMPY-02851	RANK/TNFRSF11A Protein, Rat, Recombinant (His)	Rat	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPY-02726	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-03674	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-03364	RANKL/TNFSF11/CD254 Protein, Human, Recombinant	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPJ-00607	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thy...
TMPK-00717	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)	Human	HEK293
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPK-00591	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His)	Mouse	HEK293
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPY-06561	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPK-00716	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244)	Human	HEK293
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ...
TMPY-01471	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-00537	RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-03527	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPJ-01472	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)	Mouse	Human Cells
	Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thy...
TMPJ-01466	Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)	Human	Human Cells
	TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits ...
TMPH-02147	TACR1 Protein, Human, Recombinant (GST)	Human	E. coli
	This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor ...
TMPH-01767	NPY2R Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY a...
TMPH-01294	EDNRA Protein, Human, Recombinant (His)	Human	Yeast
	Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
TMPH-03749	CYSLTR1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and...
TMPJ-00253	OPG Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulat...
TMPH-02960	TNFSF11 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator...
TMPJ-00217	Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	Human Cells
	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai...
TMPJ-00225	Siglec-15 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai...
TMPH-02264	TNFSF11 Protein, Human, Recombinant (His)	Human	HEK293
	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator...
TMPH-02417	Albumin Protein, Cynomolgus, Recombinant (His & Myc)	Cynomolgus	HEK293
	Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of...
TMPH-02210	TRAF6 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/u...
TMPJ-00434	Siglec-15 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Human Cells
	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai...
TMPH-00301	Serum albumin Protein, Bovine, Recombinant (His & Myc)	Bovine	Yeast
	Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of...
TMPH-02416	Albumin Protein, Macaca fascicularis, Recombinant (Yeast, His)	Cynomolgus	Yeast
	Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of...