phorbol — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4037	Phorbol	4β-Phorbol,(+)-Phorbol	PKC
	Phorbol (4β-Phorbol), a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.		PKC
TQ0198	Phorbol 12-myristate 13-acetate	PMA	NF-κB , S1P Receptor , PKC
	Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.		NF-κB , S1P Receptor , PKC
T16526	Phorbol 12,13-dibutyrate	PDBu,Phorbol dibutyrate	PKC
	Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.		PKC
TN4768	Phorbol 13-acetate		Others
	Phorbol 13-acetate is a natural product for research related to life sciences. The catalog number is TN4768 and the CAS number is 32752-29-7.		Others
T81484	Phorbol 12-tiglate
	Phorbol 12-tiglate, a derivative of Phorbol, which in turn is a hydrolyzed product of Croton oil, plays a role in tumor promotion through activation of protein kinase C. This compound and its related derivatives are empl...
T26386	4alpha-PDD	4α-Phorbol 12,13-didecanoate
	4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.
T72533	4-Deoxy-4α-phorbol
	4-Deoxy-4α-phorbol, a tetracyclic diterpene identified in E. desmondi, serves as a precursor in the semisynthesis of compounds inhibiting HIV-1-induced cytopathic effects in MT-4 cells and the creation of 4α-phorbol este...
T83526	(Rac)-Phorbol-12-(2-methylbutyrate)
	(Rac)-Phorbol-12-(2-methylbutyrate), a natural product, can be isolated from croton oil [1].
T22471	12-O-Tiglylphorbol-13 –isobutyrate		Others
	The compound is extracted from Croton tiglium dried fruit.		Others
TN1441	Beta-Tocopherol		ERK , MAPK
	Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).		ERK , MAPK
TN1110	Shanziside	Shanzhiside	IL Receptor
	Shanziside (Shanzhiside) has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood...		IL Receptor
T3889	Platycodin D		Prostaglandin Receptor , AMPK
	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1...		Prostaglandin Receptor , AMPK
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy...
T28975	Tigilanol tiglate	EBC-46,EBC 46,EBC46
	Tigilanol tiglate is a phorbol ester and acts as a protein kinase C regulator along with other related compounds.
T68654	Sapintoxin D
	Sapintoxin D is a fluorescent phorbol ester and selective activator of protein kinase C.
TN5852	Oleuropeic acid
	(+)-Oleuropeic acid shows potent in vitro antitumor-promoting activity, it also suppresses an in vivo two-stage carcinogenesis induced with nitric oxide and 12-O-tetradecanoyl phorbol 13-acetate (TPA) on mouse skin.
TN1228	25S-Inokosterone		TNF
	25S-Inokosterone exhibits potent inhibition against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. 25S-Inokosterone has excellent anti-atopy activity, thus 25S-Inokosterone could be...		TNF
TN1227	25R-Inokosterone		TNF
	25R-Inokosterone exhibits potent inhibition against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. 25R-Inokosterone has excellent anti-atopy activity, thus 25R-Inokosterone could be...		TNF
T37278	2-chloro Stearic Acid
	2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate . It induces DNA release from prim...
T36412	Multiflorenol
	Multiflorenol is a triterpene that has been found in T. kirilowii seeds.1 It inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate in a co...