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MAPK MAPK Beta-Tocopherol

Beta-Tocopherol

Catalog No. TN1441   CAS 148-03-8

Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.

Beta-Tocopherol, CAS 148-03-8
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.
Targets&IC50 MAPK ,   ERK
In vitro Adhesion induced by PMA stimulation was prevented by 44.5% by physiological concentrations of alpha-tocopherol. Under the same experimental conditions, Beta-Tocopherol, an analogue of alpha-tocopherol, produced 11% inhibition of adhesion. Cell response gradually increased from 0 to 24 h of alpha-tocopherol treatment. Only a slight time dependency of Beta-Tocopherol inhibition was observed. Another human erythroleukemia cell line (K562) and the human monocyte tumor cell line U937 showed 5.0 and 11.2% inhibition, respectively. Similar to alpha-tocopherol, the protein kinase C inhibitor, Calphostin C, and the MAPK inhibitor, PD98059, prevented PMA-induced cell adhesion. An inhibition of ERK-1 phosphorylation was observed for alpha-tocopherol only in HEL, implying that MAP kinase pathway is involved in this cell line.
Molecular Weight 416.7
Formula C28H48O2
CAS No. 148-03-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Differential inhibition by α±- and β-tocopherol of human erythroleukemia cell adhesion: role of integrinsFree Radic Biol Med. 2001 Jun 15;30(12):1381-9.

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