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4alpha-PDD

Catalog No. T26386 CAS 27536-56-7

Synonyms: 4α-Phorbol 12,13-didecanoate

4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.

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4alpha-PDD, CAS 27536-56-7

Pack Size	Availability	Price/USD	Quantity
1 mg	35 days	$ 250.00
5 mg	35 days	$ 1,060.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.

Synonyms	4α-Phorbol 12,13-didecanoate
Molecular Weight	672.93
Formula	C40H64O8
CAS No.	27536-56-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chen CK, Hsu PY, Wang TM, Miao ZF, Lin RT, Juo SH. TRPV4 Activation Contributes Functional Recovery from Ischemic Stroke via Angiogenesis and Neurogenesis. Mol Neurobiol. 2017 Jun 9. doi: 10.1007/s12035-017-0625-0. [Epub ahead of print] PubMed PMID: 28597396. 2. Kamakura T, Kondo M, Koyama Y, Hanada Y, Ishida Y, Nakamura Y, Yamada T, Takimoto Y, Kitahara T, Ozono Y, Horii A, Imai T, Inohara H, Shimada S. Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia. Audiol Neurootol. 2016;21(4):268-274. Epub 2016 Oct 6. PubMed PMID: 27705979. 3. Hong Z, Tian Y, Qi M, Li Y, Du Y, Chen L, Liu W, Chen L. Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons. Front Mol Neurosci. 2016 Aug 26;9:77. doi: 10.3389/fnmol.2016.00077. eCollection 2016. PubMed PMID: 27616980; PubMed Central PMCID: PMC4999446. 4. Qu YJ, Zhang X, Fan ZZ, Huai J, Teng YB, Zhang Y, Yue SW. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. Biomed Res Int. 2016;2016:6978923. doi: 10.1155/2016/6978923. Epub 2016 Jun 5. PubMed PMID: 27366753; PubMed Central PMCID: PMC4913001.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

4alpha-PDD 27536-56-7 4alphaPDD 4alpha PDD 4alpha-Phorbol 12,13-didecanoate 4α-Phorbol 12,13-didecanoate 4a-PDD 4α-PDD 4a-Phorbol 12,13-didecanoate inhibitor inhibit

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