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Search Result

Search Results for " plpro "

Targets

SARS-CoV

19

Compounds

1

Natural Products

5

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T12502 PLpro inhibitor SARS-CoV
PLpro inhibitor is a potent papain-like protease (PLpro) inhibitor(IC50 of 2.6 uM)
T78704 PLpro/RBD-IN-1 SARS-CoV
PLpro/RBD-IN-1 (Compound 5) serves as a dual inhibitor targeting both the SARS-CoV-2 papain-like protease (PLpro) and the receptor-binding domain (RBD) of the spike protein, exhibiting half-maximal inhibitory concentrati...
T62991 Mpro/PLpro-IN-1
Mpro/PLpro-IN-1 (Compound 29) is a dual-acting inhibitor of SARS-CoV-2 protease.Mpro/PLpro-IN-1 is also a potent inhibitor of Mpro/PLpro, with micromolar inhibition of M pro (IC50:1.72 μM) and submicromolar inhibition of...
T9606 TC-067533 SARS-CoV
TC-067533 is a Papain-like protease inhibitor with an IC50 of 8.7 μM.
T3089 6-Thioguanine 6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine Apoptosis , DNA Methyltransferase , SARS-CoV , Endogenous Metabolite , DUB , Autophagy
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T81203 SARS-CoV-2-IN-68 SARS-CoV
SARS-CoV-2-IN-68 (compound 6C) is a covalent inhibitor of both SARS-CoV-2 PLpro and Mpro, exhibiting potent antiviral properties by targeting the Zn-finger domain of PLpro [1].
T79426 SARS-CoV-2-IN-61 SARS-CoV
SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 µM and demonstrating antiviral activities [1].
T63735 SP inhibitor 1
SP inhibitor 1 is an inhibitor of SARS-CoV-2 replication at non-toxic concentrations (0.3250<5.98 μM) in vitro. SP inhibitor 1 is a selective inhibitor of SARS-CoV-2 stinger protein (SP), acting on SP protein (IC50: 3.26...
T60841 SARS-CoV-2-IN-23
SARS-CoV-2-IN-23 (compound GRL-0617) is an inhibitor of SARS-COV-2 papain-like protease (PLpro) (IC 50 = 2.3 μM) [1].
T63292 SARS-CoV-2-IN-24
SARS-CoV-2-IN-24 is a potent inhibitor of papain-like proteases (PLpro) that induces conformational changes in SARS-COV-2 papain-like proteases, inhibits SARS-COV-2 replication, and can be used to study SARS-CoV-2.
T62928 XR8-69
XR8-69 is a SARS-CoV-2 PLpro inhibitor. XR8-69 has a low micromolar antiviral effect in SARS-CoV-2 infected human cells.
T63461 INSCoV-600K(1)
INSCoV-600K(1) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-600K(1) has shown research potential against SARS-CoV-2 infection.
T63483 INSCoV-614(1B)
INSCoV-614(1B) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-614(1B) has shown research potential for SARS-CoV-2 infection.
T63462 INSCoV-601I(1)
INSCoV-601I(1) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-600I(1) has shown research potential against SARS-CoV-2 infection.
T63443 XR8-89
XR8-89, a potent inhibitor of papain-like protease (PLpro), exhibits an IC50 value of 0.1 μM and effectively hinders SARS-CoV-2 replication by inducing conformational changes in the SARS-COV-2 papain-like protease. This ...
T78953 SIMR3030 SARS-CoV
SIMR3030, a potent inhibitor of SARS-CoV-2 PLpro, possesses an IC50 of 0.0399 µg/mL and demonstrates antiviral activity by diminishing the expression of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030...
T61500 PLP_Snyder530
PLP_Snyder530 is a potent papain-like protease (PL pro ) inhibitor. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-C...
T81202 SARS-CoV-2-IN-69 SARS-CoV
SARS-CoV-2-IN-69 (Compound 7E) is a potent, non-covalent inhibitor of the SARS-CoV-2 main protease (M^pro) with an EC50 of 7.4 μM and also inhibits the papain-like protease (PL^pro) [1].
T75065 Antiviral agent 25
Antiviral agent 25 (compound 6g), a novel non-peptide analog covalent inhibitor of SARS-CoV-2 3CL pro, exhibits robust inhibitory activity against both SARS-CoV-2 3CL pro and SARS-CoV-2 PL pro, with IC50 values of 0.118 ...
Cat No. Product Name Synonyms Targets
T3S0136 4'-O-Methylbavachalcone O-Methylbroussochalcone B SARS-CoV
4'-O-Methylbavachalcone (O-Methylbroussochalcone B) is isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity (IC50: 10.1 μM).

Natural Products

4'-O-Methylbavachalcone
T3S0136
Synonym: O-Methylbroussochalcone B
Target: SARS-CoV

Recombinant Proteins

Species：
SARS (3)
SARS-CoV-2 (2)
Expression System：
E. coli (5)
Tag：
C-His (2)
N-His (1)
N-His-Avi (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPK-01384 SARS PLpro/papain-like protease Protein (His) SARS E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPK-01352 SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) SARS E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPY-04894 SARS-CoV (strain WH20) Plpro/papain-like protease (His) SARS E. coli
SARS-CoV (strain WH20) Plpro/papain-like protease (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.65 kDa and the accession number is AAX16193.1.
TMPJ-01431 SARS-CoV-2 Papain-Like Protease Protein SARS-CoV-2 E. coli
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a pap...
TMPY-05682 SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His) SARS-CoV-2 E. coli
SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His) is expressed in E. coli expression system. The predicted molecular weight is 36.79 kDa and the accession number is QVD65746.1.
Cat No. Product Name
L1710 Anti-COVID-19 Compound Library

1133 compounds
A unique collection of 1133 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents；

Libraries

Anti-COVID-19 Compound Library
L1710
Compounds: 1133
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