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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15133 | Dinoprost | Prostaglandin F2a,PGF2α | Endogenous Metabolite |
Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient. | |||
T20939 | Bimatoprost acid | 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α | GPR |
Bimatoprost acid (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relative potency of 756% compared to PGF2α for binding to the FP... | |||
T22285 | Carboprost | 15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α | Prostaglandin Receptor |
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone. | |||
T4546 | Dinoprost tromethamine salt | Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,Prostaglandin F2α THAM | Apoptosis , Endogenous Metabolite , Prostaglandin Receptor , Autophagy , PROTAC Linker |
Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. | |||
T30452 | Bimatoprost isopropyl ester | 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester | |
Bimatoprost isopropyl ester is an F-series prostaglandin analog, which has been approved as a hypotensive drug. | |||
T21965 | MBCQ | PDE | |
MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5. | |||
T29725 | AGN-191129 | AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T | |
AGN-191129, also known as Prostaglandin F2α alcohol methyl ether (PGF2α-OMe), is an analog of PGF2α in which the C-1 carboxyl group has been replaced by an O-methyl ether. The compound is reported to retain ocular hypote... | |||
T37991 | 15-keto Prostaglandin F2α | 15-keto Prostaglandin F2α,15-keto PGF2α | Endogenous Metabolite , Prostaglandin Receptor |
15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits. | |||
T36146 | 13,14-dihydro Prostaglandin F2α | 13,14-dihydro Prostaglandin F2α,13,14-dihydro PGF2α | |
13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value... | |||
T37326 | Prostaglandin F2α 1,11-lactone | Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone | Prostaglandin Receptor |
Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) is a lipid-soluble prodrug of Prostaglandin F2α and can be used in studies about treating glaucoma. Prostaglandin F2α 1,11-lactone is active as an antifertility agent w... | |||
T36619 | Aligeron | Prostaglandin Receptor | |
Aligeron is a non-selective prostaglandin (PG) antagonist that inhibits PGF2α- and PGE2-induced decreases in blood pressure in cats, and can be used to inhibit PGF2α-induced diarrhea in mice and PGE2-induced paw edema in... | |||
TQ0203 | Tafluprost | MK2452,AFP-168 | Prostaglandin Receptor |
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α. | |||
T10960L | Darbufelone mesylate | CI-1004 mesylate | Prostaglandin Receptor , LTR |
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 value of 20 μM. | |||
T10381 | AS2717638 | Others | |
AS2717638 is an orally active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50: 38 nM for hLPA5). It also significantly improves PGF2α-, PGE2-, and AMPA-induced allodynia. | |||
T12285 | Ebopiprant | OBE022,OBE-022 | Others |
Ebopiprant (OBE022) is an orally available, selective and potent prostaglandin F2α (PGF2α) receptor antagonist that interferes with the binding of PGF0126α to the FPR and can be used in the study of obesity. | |||
T10960 | Darbufelone | CI-1004 | Prostaglandin Receptor , LTR |
Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1. | |||
T5847 | Cloprostenol sodium salt | ICI 80996 sodium salt,DL-Cloprostenol sodium,Cloprostenol sodium | Prostaglandin Receptor |
Cloprostenol sodium salt (ICI 80996 sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α. | |||
T37327 | Prostaglandin F2α 1,15-lactone | Prostaglandin F2α 1,15-lactone | |
PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, w... | |||
T37995 | 16-phenoxy tetranor Prostaglandin F2α | 16-phenoxy tetranor Prostaglandin F2α | |
16-phenoxy PGF2α is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. | |||
T38196 | Prostaglandin F2α isopropyl ester | Prostaglandin F2α isopropyl ester | |
PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application ... |