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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4663 | QX77 | Others , Autophagy | |
QX77 is a chaperone-mediated autophagy (CMA) activator. | |||
T50093 | MASM7 | Others | |
MASM7 also known as MASM7, is a compound used as a molecular structural unit. It is a mitochondrial fusion protein activator that enables mitochondrial fusion via mitochondrial fusion proteins. | |||
T1637 | Deferoxamine Mesylate | desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM | Mitophagy , Beta Amyloid , Others , Ferroptosis , HIF/HIF Prolyl-Hydroxylase , Autophagy |
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i... | |||
T6337 | RepSox | ALK5 Inhibitor II,SJN 2511,E-616452 | ALK , TGF-beta/Smad |
RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells. | |||
T78170 | Kras4B G12D-IN-1 | Ras | |
Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mut... | |||
T80514 | TAT-SAMβA | PKC | |
TAT-SAMβA, an RNAENFDRF (SAMβA) peptide conjugated to the TAT 47–57 protein-derived cell-penetrating peptide, acts as a selective antagonist of the Mfn1-βIIPKC association. It has been shown to protect mouse embryonic fi... | |||
T37023 | MB 0223 | ||
Dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fu... | |||
T36321 | C6 Urea Ceramide | ||
C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It i... | |||
T78520 | CYT296 | Others | |
CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibro... | |||
T69195 | UC-857993 | ||
UC-857993, a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), effectively suppresses catalytic activity. In addition to inhibiting ERK and Ras activation, it also hampers the growth of mouse embryonic fibroblasts... | |||
T37487 | 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE | ||
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE b... | |||
T38280 | C22 dihydro 1-Deoxyceramide (m18:0/22:0) | C22 dihydro 1-Deoxyceramide (m18:0/22:0) | |
C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alan... | |||
T38284 | C24 dihydro 1-Deoxyceramide (m18:0/24:0) | C24 dihydro 1-Deoxyceramide (m18:0/24:0) | |
C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alan... |