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C24 dihydro 1-Deoxyceramide (m18:0/24:0)

Catalog No. T38284 CAS 1645269-63-1

Synonyms: C24 dihydro 1-Deoxyceramide (m18:0/24:0)

C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0/24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, and sciatic nerve at one, three, and six months of age.4

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C24 dihydro 1-Deoxyceramide (m18:0/24:0) Chemical Structure

C24 dihydro 1-Deoxyceramide (m18:0/24:0), CAS 1645269-63-1

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5 mg	Inquiry	$ 810.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	C24 dihydro 1-Deoxyceramide (m18:0/24:0)
Molecular Weight	636.147
Formula	C42H85NO2
CAS No.	1645269-63-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 20 mg/mL

Ethanol:PBS (pH 7.2) (1:1): 0.50 mg/mL

Ethanol: 30 mg/mL

DMSO: 20 mg/mL

References and Literature

1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016). 2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017). 3. Alecu, I., Tedeschi, A., Behler, N., et al. Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J. Lipid. Res. 58(1), 42-59 (2017). 4. Schwartz, N.U., Mileva, I., Gurevich, M., et al. Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 141, 40-48 (2019).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

C24 dihydro 1-Deoxyceramide (m18:0/24:0) 1645269-63-1 C24 dihydro 1 Deoxyceramide (m18:0/24:0) C24 dihydro 1-Deoxyceramide C24 dihydro 1Deoxyceramide (m18:0/24:0) m18:0/24:0 C-24 dihydro 1-Deoxyceramide (m18:0/24:0) inhibitor inhibit

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