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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36256 | LC-2 | LC 2,PROTAC KRASG12C Degrader-LC-2,LC2 | PROTACs |
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recru... | |||
T41215 | LC 2 Epimer | ||
Negative control for LC 2. | |||
T72286 | LC kinetic stabilizer-2 | ||
LC Kinetic Stabilizer-2 is a powerful stabilizer for amyloidogenic immunoglobulin light chains (LC), demonstrating significant efficacy with an EC50 of 24 nM. | |||
T8656 | CAY10404 | 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T | Apoptosis , Akt , COX |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel... | |||
T3S1775 | Tectochrysin | NSC 80687,Techtochrysine,Techtochrysin | NF-κB , STAT |
1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apoptotic cell death in NSC-LC cells through ac... | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T40189 | MRTX849 acid | MRTX849 acid | |
MRTX849 acid, a derivative of MRTX849, is employed in the synthesis of PROTAC LC-2. LC-2, a potent and pioneering PROTAC, exhibits the ability to efficiently degrade endogenous KRAS G12C with DC50 values ranging between ... | |||
T40874 | 2-Nitrobenzaldehyde semicarbazone 13C,15N2 | 2-Nitrobenzaldehyde semicarbazone 13C,15N2 | |
2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis. | |||
T40190 | MRTX849 ethoxypropanoic acid | ||
MRTX849 ethoxypropanoic acid is a compound that contains a ligand for KRAS G12C and a PROTAC linker. It is commonly employed in the synthesis of PROTAC LC-2, which is a highly effective and innovative PROTAC. LC-2 has be... | |||
T63583 | RET-IN-11 | ||
RET-IN-11 is a potent and selective RET inhibitor that acts on RET (IC50: 6.20 nM) and RETV804M (IC50: 18.68 nM).RET-IN-11 induces apoptosis.RET-IN-11 exhibits anti-proliferative and migratory effects in LC-2/ad cells. R... | |||
T74764 | Adenosylhomocysteinase | ||
Adenosylhomocysteinase (SAHH; AHCY), a highly conserved enzyme, reversibly catalyzes S-adenosylhomocysteine (SAH) into adenosine and L-homocysteine. Its level in serum exosomes serves as a prognostic biomarker for HBV-LC... | |||
T35515 | 3-Acetyldeoxy Nivalenol-13C17 | 3-Acetyldeoxy Nivalenol-13C17 | |
3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In ... | |||
T37928 | 13C6 Glucosylsphingosine (d18:1) | ||
13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS.... | |||
T35697 | Lauric Acid-13C | ||
Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Laur... | |||
T35521 | Aflatoxin G2-13C17 | Aflatoxin G2-13C17 | |
Aflatoxin G2-13C17is intended for use as an internal standard for the quantification of aflatoxin G2by GC- or LC-MS. Aflatoxin G2is a mycotoxin that has been found inAspergillus.1It is lethal to ducklings (LD50= 2.83 mg/... | |||
T36537 | Nitrofurantoin-13C3 | Nitrofurantoin-13C3 | |
Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1In vivo, nitrofurantoin (25-100 mg/kg) reducesE. colirep... | |||
T63573 | WF-47-JS03 | ||
WF-47-JS03 is a selective and potent inhibitor of RET kinase that crosses the blood-brain barrier and is more than 500-fold more selective for the kinase insertion domain receptor (KDR).WF-47-JS03 acts on Ba/F3 cells tra... | |||
T69758 | Flutamide-d7 | ||
Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted ... | |||
T71285 | Metaxalone-d6 | ||
Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264... | |||
T35602 | O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine | ||
O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine is a major metabolite of the calcium channel inhibitor amlodipine .1 1.Taguchi, R., Naito, T., Sato, H., et al.Validated LC-MS/MS method for the simultaneous determin... |