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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11635 | IL-17A antagonist 1 | IL Receptor | |
IL-17A antagonist 1 is an IL-17A antagonist for the study of interleukin-related inflammatory and immune diseases. | |||
T9448 | IL-17A inhibitor 1 | IL Receptor | |
IL-17A inhibitor 1 is a IL-17A inhibitor with IC50 of <9.45 nM in alphalisa assay. IL-17A inhibitor 1 inhibits HT-29 cells with IC50 of 9.3 nM. | |||
T40355 | IL-17A modulator-2 | ||
IL-17A modulator-2, exhibits inhibitory properties towards IL-17A, with a pIC50 of 8.3. Its effectiveness lies in attenuating the biological effects associated with IL-17A activity. IL-17A modulator-2 finds utility in th... | |||
T40354 | IL-17A modulator-1 | ||
IL-17A modulator-1 is an effective inhibitor of IL-17A activity, exhibiting a pIC 50 value of 8.2. This compound holds great promise for studying diseases and disorders that involve the modulation of IL-17A, such as immu... | |||
T40116 | IL-17A inhibitor 2 | ||
IL-17A inhibitor 2 is an IL-17A inhibitor for treating psoriasis, rheumatoid arthritis, and multiple sclerosis. | |||
T11636 | IL-17A antagonist 3 | IL Receptor | |
IL-17A antagonist 3 is an IL-17A antagonist. | |||
T14369 | AZD-0284 | ROR | |
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. | |||
T76797 | Anti-Human IL-17A | ||
Anti-Human IL-17A is a fully human anti- interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis [1] . | |||
T72549 | IL-17A modulator-3 | ||
IL-17A Modulator-3, an inhibitor of IL-17A/A, exhibits an IC 50 value of less than 10 μM. It is utilized in research related to inflammation, cancer, and autoimmune diseases. | |||
T6668 | SGC-CBP30 | Epigenetic Reader Domain , Histone Acetyltransferase | |
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM). | |||
T4050 | GSK2981278 | ROR gama modulator 1 | ROR |
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). | |||
TN7236 | Cephalandole B | IL Receptor | |
cephalandole B, an indole alkaloid isolated from cyanide, significantly inhibited IL-17A gene expression and suppressed IL-17A luciferase reporter in Jukat cells in a dose-dependent manner. | |||
T38105 | Ixekizumab | LY2439821 | IL Receptor , Interleukin |
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A with a Kd value of <3 pM.Ixekizumab blocks the binding of IL-17A to IL-17RA but not to other IL-17 ... | |||
TN6393 | Fulvotomentoside A | Others | |
Fulvotomentoside A could decrease overexpression of IL-6 and IL-17A, and increase the expression of specific transcription factor Foxp3 of regulatory T cells significantly in intestine. It may be one of the mechanisms th... | |||
T4403 | AX-024 hydrochloride | AX-024 HCl | IL Receptor , TNF , COX , IFNAR , Interleukin |
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. | |||
T9930 | Secukinumab | IL Receptor | |
Secukinumab is a fully humanized monoclonal anti-IL-17A antibody and the first in its class to be approved by the US Food and Drug Administration for the treatment of moderate to severe plaque psoriasis. | |||
T77677 | 12R-LOX-IN-2 | Lipoxygenase | |
12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein... | |||
T77030 | Gumokimab | ||
Gumokimab (AK 111), a monoclonal antibody, targets IL-17A and is utilized in researching psoriasis and ankylosing spondylitis. It competitively inhibits the interaction between human IL-17A and its receptor, IL-17R. | |||
T76256 | Erepdekinra | ||
Erepdekinra is an interleukin-17A (IL-17A) receptor antagonist [1] . | |||
T76953 | Xeligekimab | ||
Xeligekimab (GR 1501) is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A) to inhibit the pro-inflammatory cascade [1]. |