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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S0071 | Fraxinellone | HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1 | |
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding... | |||
T3169 | KC7F2 | HIF/HIF Prolyl-Hydroxylase , HIF | |
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity. | |||
T22022 | Adaptaquin | HIF | |
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2]. | |||
T0244 | Tilorone dihydrochloride | Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR | |
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions. | |||
T5392 | TP0463518 | HIF/HIF Prolyl-Hydroxylase | |
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively). | |||
T7880 | IOX4 | HIF/HIF Prolyl-Hydroxylase | |
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM) | |||
T13398 | ZINC13466751 | HIF | |
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM). | |||
T7848 | PT-2385 | HIF/HIF Prolyl-Hydroxylase , HIF | |
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM). | |||
T5537 | IDF-11774 | HIF/HIF Prolyl-Hydroxylase , HIF | |
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM). | |||
T12675L | PT2399 | HIF/HIF Prolyl-Hydroxylase , HIF | |
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM). | |||
T13050 | SYP-5 | HIF/HIF Prolyl-Hydroxylase , HIF | |
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis. | |||
T4106 | MK-8617 | MK8617 | HIF/HIF Prolyl-Hydroxylase |
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM). | |||
T2488 | BAY 87-2243 | Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF | |
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1). | |||
T21653 | 1,4-DPCA | HIF/HIF Prolyl-Hydroxylase | |
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH). | |||
T15219 | Enarodustat | JTZ-951 | Others , HIF/HIF Prolyl-Hydroxylase |
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment. | |||
T5S2347 | Deoxyshikonin | Arnebin 7 | Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial |
1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ... | |||
T64336 | Izilendustat | HIF/HIF Prolyl-Hydroxylase | |
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis. | |||
T7802 | M1001 | HIF/HIF Prolyl-Hydroxylase , HIF | |
M1001 is a HIF-2α agonist. | |||
T29797 | AKB-6899 | AKB6899 | VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF |
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in... | |||
T21806 | HNHA | HDAC | |
HNHA is an inhibitor of HDAC. |