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IOX4

Catalog No. T7880 CAS 1154097-71-8

IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)

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IOX4, CAS 1154097-71-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 48.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 190.00
50 mg	In stock	$ 343.00
100 mg	In stock	$ 515.00
200 mg	In stock	$ 733.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 98.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
Targets&IC50	PHD2:1.6 nM
In vivo	IOX4 as a highly potent and selective inhibitor of human PHD2, As shown by studies with mice, IOX4 is useful for in vivo work;?it will then be useful for investigations on the suitability of the PHDs as targets for cerebral diseases such as stroke.?The combined kinetic and biophysical analyses reveal that IOX4 (and IOX2) compete with 2OG for binding to PHD2;?the triazole rings of the inhibitors bind in the pocket occupied by the CH2CH2COOH side chain of 2OG.?The results thus reveal the potential of non-acid containing PHD inhibitors—an important finding given the potential of HIFα upregulation mediated by PHD inhibition in the treatment of stroke, as acids do not often permeate the blood-brain barrier efficiently[1].

Molecular Weight	328.33
Formula	C15H16N6O3
CAS No.	1154097-71-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (253.80 mM), Sonication is recommended.

References and Literature

1. Chan Mun Chiang, Atasoylu Onur, Hodson Emma,et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain[J]. Plos One, 10(7):e0132004-. 2. Murray J K , Balan C , Allgeier A M , et al. Dipeptidyl-Quinolone Derivatives Inhibit Hypoxia Inducible Factor-1α Prolyl Hydroxylases-1, -2, and -3 with Altered Selectivity[J]. Journal of Combinatorial Chemistry, 2010, 12(5):676-686.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library Epigenetics Compound Library Anti-Metabolism Disease Compound Library CNS-Penetrant Compound Library Anti-Pancreatic Cancer Compound Library HIF-1 Signaling Pathway Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Glucosamine dencichine TP0463518 HIF-2α-IN-2 Chloramphenicol Hydralazine hydrochloride Oroxylin A KC7F2

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IOX4 1154097-71-8 Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF-PH HIFs Hypoxia-inducible factors inhibit IOX 4 Inhibitor IOX-4 inhibitor

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