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HNHA

Catalog No. T21806 CAS 926908-04-5

HNHA is an inhibitor of HDAC.

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HNHA, CAS 926908-04-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 63.00
2 mg	In stock	$ 89.00
5 mg	In stock	$ 127.00
10 mg	In stock	$ 243.00
25 mg	In stock	$ 581.00
50 mg	In stock	$ 829.00
100 mg	In stock	$ 1,150.00
500 mg	In stock	$ 2,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 138.00

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Purity: 98.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HNHA is an inhibitor of HDAC.
Targets&IC50	HDAC:100 nM
In vitro	Treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion. HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080).
In vivo	Several HDAC inhibitors, including MS-27-275 and a hydroxyamide-based HDAC inhibitors such as SAHA have been investigated extensively and shown to inhibit tumor growth in vivo.

Molecular Weight	303.42
Formula	C17H21NO2S
CAS No.	926908-04-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 15mg/mL(49.44mM)

DMSO: 15mg/mL(49.44mM)

References and Literature

1. Dong H K , Lee J , Kim K N , et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor[J]. Biochemical & Biophysical Research Communications, 2007, 356(1):233-238.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NF-κB Signaling Compound Library Histone Modification Compound Library Anti-Breast Cancer Compound Library Epigenetics Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library NO PAINS Compound Library Chromatin Modification Compound Library

Related Products

Related compounds with same targets

HDAC6-IN-25 BRD4097 GK718 BRD 4354 ditrifluoroacetate LMK-235 Tubastatin A Hydrochloride SIS17 SGC-UBD253

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HNHA 926908-04-5 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases HIF/HIF Prolyl-Hydroxylase inhibit Inhibitor HIF-PH HIFs FM3A cells MCF-7 cells Anti-cancer activity Matrix metalloproteinases Breast cancer Hypoxia-inducible factors MMP inhibitor

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