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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6053 | Turofexorate Isopropyl | XL335,FXR-450,WAY-362450 | FXR , Autophagy |
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM | |||
T40302 | FXR/TGR5 agonist 1 | ||
FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease. | |||
T64144 | FXR antagonist 1 | ||
FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation... | |||
T74996 | FXR agonist 3 | ||
FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ... | |||
T72889 | FXR agonist 4 | ||
FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ... | |||
T75160 | FXR agonist 5 | ||
FXR agonist 5 (compound 1), an FXR agonist, is utilized in research targeting diseases or disorders associated with metabolic inflammation [1]. | |||
T74754 | FXR antagonist 2 | ||
Compound A-26, also known as FXR antagonist 2, is a diarylamide derivative that functions as a moderate FXR antagonist. It is utilized in researching hyperlipidemia and type 2 diabetes [1]. | |||
T2015 | Fexaramine | FXR , Autophagy | |
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds. | |||
T7886 | Nidufexor | FXR , Autophagy | |
Nidufexor is an agonist for the farnesoid X receptor (FXR). | |||
T2233 | GW 4064 | FXR , Autophagy | |
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM). | |||
T15806 | LY2562175 | FXR , Autophagy | |
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM). | |||
T6344 | Sevelamer hydrochloride | Sevelamer HCl | FXR , Autophagy |
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption. | |||
T31587 | DY268 | DY 268,DY-268 | FXR |
DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM). | |||
T4379 | Tropifexor | LJN452 | FXR , Autophagy |
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. | |||
T7436 | Cilofexor | FXR , Autophagy | |
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist. | |||
T11428 | Glyco-Obeticholic acid | FXR | |
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR). | |||
T13092 | Tauro-Obeticholic acid | FXR | |
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). | |||
T2601 | Vidofludimus | SC12267,4sc-101 | Dehydrogenase , DNA/RNA Synthesis , Interleukin |
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). | |||
T0847 | Chenodeoxycholic acid | CDCA,Chenodiol | Potassium Channel , FXR , Endogenous Metabolite , Autophagy |
Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as ... | |||
T2939 | Forskolin | Coleonol,Colforsin | FXR , Adenylyl cyclase , AChR , Autophagy |
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the... |