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DY268

Name: DY268
Brand: TargetMol
SKU: T31587
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31587Cas No. 1609564-75-1

Alias DY-268, DY 268

DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM).

DY268

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Purity: 99.75%

Catalog No. T31587Alias DY-268, DY 268Cas No. 1609564-75-1

DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM).

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$258	In Stock
50 mg	$478	In Stock
100 mg	$689	In Stock
500 mg	$1,480	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Batch Information

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Purity:99.75%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM).
Targets&IC50	FXR:7.5 nM
Synonyms	DY-268, DY 268

Chemical Properties

Molecular Weight	560.66
Formula	C₃₀H₃₂N₄O₅S
Cas No.	1609564-75-1
Smiles	C(NC1=CC(S(=O)(=O)N2CCOCC2)=C(C)C=C1)(=O)C=3C(=NN(CC4=CC(OC)=CC=C4)C3)C5=CC=C(C)C=C5
Relative Density.	1.30 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (89.18 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7836 mL	8.9181 mL	17.8361 mL	89.1806 mL
5 mM	0.3567 mL	1.7836 mL	3.5672 mL	17.8361 mL
10 mM	0.1784 mL	0.8918 mL	1.7836 mL	8.9181 mL
20 mM	0.0892 mL	0.4459 mL	0.8918 mL	4.4590 mL
50 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7836 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc