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Search Results for " fx "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T15362	FX-11	LDHA Inhibitor FX11	Dehydrogenase
	FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce...		Dehydrogenase
T7582	Tafamidis meglumine	Fx-1006A	Others
	Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade		Others
T4565	Tafamidis	Fx-1006A	Others
	Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR di...		Others
T78562	FX-06	Fibrin-derived peptide Bβ15-42
	FX-06 (Fibrin-derived peptide Bβ15-42) is a peptide derived from the fibrin Bbeta chain. It interacts with VE-cadherin to inhibit leukocyte transmigration and initiate VE-cadherin-mediated signaling pathways. This compou...
T4089	FX1		Apoptosis , BCL
	FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).		Apoptosis , BCL
T73519	FX-909
	FX-909 is a covalent peroxisome proliferator-activated receptor gamma ( PPARG ) inverse agonist. FX-909 can be used for the research of cancer .
T9253	CPFX4158		Antibacterial
	CPFX4158 is a mannose deriviative and an antibacterial agent that is potentially useful in transgenic humanized- CEACAM6 mouse.		Antibacterial
T72889	FXR agonist 4
	FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ...
T39035	FXIa-IN-6
	FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases ( K i = 0.3 nM). FXIa-IN-6 also demonstrated excellent pharmacokinetics (PK) profile (high oral bioavailability and low ...
T11341	FXIa-IN-1		Others
	FXIa-IN-1 is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.		Others
T74996	FXR agonist 3
	FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ...
T82361	FXIIa-IN-1
	XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 97.8 nM, utilized in the study of thrombosis [1].
T82360	FXIIa-IN-2
	XIIa-IN-1-IN-2 (Compound 21) serves as a potent Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 62.2 nM, utilized primarily in thrombosis research [1].
T64098	FXIa-IN-10
	FXIa-IN-10 is a potent, orally bioavailable inhibitor of Activator XI (FXIa) (Ki: 0.17 nM).
T70458	FXIa-6f
	FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species
T64099	FXIa-IN-9
	FXIa-IN-9 (compound 3f) is a potent, selective inhibitor of FXIa, demonstrating strong binding affinity through hydrogen bond formation (human FXIa K i : 0.17 nM, rabbit FXIa K i : 0.5 nM). It exhibits anticoagulant prop...
T10878	CPFX2090		Others
	CPFX2090, a cephalosporin antibacterial compound.		Others
T64144	FXR antagonist 1
	FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation...
T64257	FXIa-IN-8
	FXIa-IN-8 is a potent and selective inhibitor of FXIa (IC50: 14.2 nM). FXIa-IN-8 exhibits anti-thrombotic effects and does not increase the risk of bleeding or significant toxicity sup>[1].
T75160	FXR agonist 5
	FXR agonist 5 (compound 1), an FXR agonist, is utilized in research targeting diseases or disorders associated with metabolic inflammation [1].
T74754	FXR antagonist 2
	Compound A-26, also known as FXR antagonist 2, is a diarylamide derivative that functions as a moderate FXR antagonist. It is utilized in researching hyperlipidemia and type 2 diabetes [1].
T40302	FXR/TGR5 agonist 1
	FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.
T62832	FXIa-IN-7
	FXIa-IN-7 is an orally active, selective factor Xia inhibitor (IC50: 0.4 nM).
T63239	FXa-IN-1
	FXa-IN-1 is an FXa inhibitor with an IC50 value of 3 nM and a Ki value of 0.7 nM that exhibits good oral bioavailability and half-life (in vivo) and can be used to study thromboembolic diseases.
T82585	Denecimig	Mim8	Factor Xa
	Denecimig (Mim8), a novel bispecific human antibody mimetic of activated coagulation factor VIII, possesses both anti-FIXa and anti-FX arms. This compound robustly enhances FX activation, thereby promoting effective hemo...		Factor Xa
T26394	6-Alkynyl-fucose	6-Alk-Fuc
	6-Alkynyl-fucose, a widely used fucosylation probe, acts by strongly inhibiting fucosylation and GDP-fucose synthetase FX and halting hepatoma invasion.
T71641	BMS-593214
	BMS-593214 is an active site-directed factor (F) VIIa inhibitor that exhibits antithrombotic and antihaemostatic properties. It acts as a direct competitive inhibitor of human FVIIa and a non-competitive inhibitor of Vii...

Compounds

FX-11

T15362

Synonym: LDHA Inhibitor FX11

Target: Dehydrogenase

Synonym: Fibrin-derived peptide Bβ15-42

Target: Apoptosis, BCL

Target: Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01101	Coagulation factor X/F10 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the...
TMPJ-01111	TSTA3 Protein, Human, Recombinant (His)	Human	E. coli
	GDP-L-Fucose Synthase is a NADP(H)-binding protein. It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-dexoymannose to GDP-L-fucose. GDP-L-Fucose is the...
TMPH-03295	Frataxin/FXN Protein, Rat, Recombinant	Rat	E. coli
	Frataxin/FXN Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is D3ZYW7.
TMPH-02660	Frataxin/FXN Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress thr...
TMPH-02661	Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress thr...
TMPH-01479	H2AFX Protein, Human, Recombinant (GST)	Human	E. coli
	H2AFX Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-01355	FXR1 Protein, Human, Recombinant (His)	Human	E. coli
	RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. FXR1 Protein, Human, Recombinant (His) is expressed in E...
TMPH-01358	FXYD3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	FXYD3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 20.5 kDa and the accession number is Q14802.
TMPH-01356	Frataxin/FXN Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Frataxin/FXN Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.1 kDa and the accession number is Q16595.