store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | Inquiry | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer. |
Targets&IC50 | LDHA, HeLa cell:23.3 μM, LDHA(HeLa cell):23.3 μM, LDHA:8 μM(Ki), DU145(cell):32 ± 1.1 μM, PC3(cell):27 ± 1.1 μM |
In vitro |
FX-11 (9 μM, 24-48 h) induces activation of AMP kinase and phosphorylation of acetyl-CoA carboxylase, its substrate. FX-11 disrupts glycolysis and modifies cellular energy metabolism in P493 cells. [1] FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. [2] |
In vivo |
FX-11 (42 µg/mouse; IP, administered daily for 10-14 days) suppresses P493 tumor growth.[1] FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) notably retards tumor growth.[2] |
Synonyms | LDHA Inhibitor FX11 |
Molecular Weight | 350.41 |
Formula | C22H22O4 |
CAS No. | 213971-34-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (642.1 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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FX-11 213971-34-7 Metabolism Dehydrogenase FX 11 LDHA Inhibitor FX11 FX11 inhibitor inhibit