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FX-11

Catalog No. T15362   CAS 213971-34-7
Synonyms: LDHA Inhibitor FX11

FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.

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FX-11 Chemical Structure
FX-11, CAS 213971-34-7
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1 mg In stock $ 41.00
5 mg In stock $ 98.00
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1 mL * 10 mM (in DMSO) In stock $ 107.00
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Purity: 98.95%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.
Targets&IC50 LDHA, HeLa cell:23.3 μM, LDHA(HeLa cell):23.3 μM, LDHA:8 μM(Ki), DU145(cell):32 ± 1.1 μM, PC3(cell):27 ± 1.1 μM
In vitro FX-11 (9 μM, 24-48 h) induces activation of AMP kinase and phosphorylation of acetyl-CoA carboxylase, its substrate. FX-11 disrupts glycolysis and modifies cellular energy metabolism in P493 cells. [1]
FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. [2]
In vivo FX-11 (42 µg/mouse; IP, administered daily for 10-14 days) suppresses P493 tumor growth.[1]
FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) notably retards tumor growth.[2]
Synonyms LDHA Inhibitor FX11
Molecular Weight 350.41
Formula C22H22O4
CAS No. 213971-34-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (642.1 mM), sonification is recommended.

TargetMolReferences and Literature

1. Le A, et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010;107(5):2037-204 2. Mohammad GH, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel). 2019;11(9):137 3. Scroggins BT, et al. Hyperpolarized [1-13C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer In Vivo predicts efficacy of targeting the Warburg effect. Clin Cancer Res 2018;24(13):3137-3148. 4. Gong Y, et al. Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets. Cell Metab. 2021;33(1):51-64.

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Keywords

FX-11 213971-34-7 Metabolism Dehydrogenase FX 11 LDHA Inhibitor FX11 FX11 inhibitor inhibit

 

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