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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36675 | ERK-IN-4 | ERK Inhibitor | ERK |
ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction. | |||
T9141 | ERK-IN-3 | ASN007 free base | ERK |
ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations. | |||
T11224 | Rineterkib | ERK-IN-1 | ERK , Raf |
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway. | |||
T11225 | ERK-IN-2 | ERK | |
ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1]. | |||
T39453 | ERK-IN-3 benzenesulfonate | ||
ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK . ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancer... | |||
T3166 | VX-11e | Vertex-11e,VTX-11e,TCS ERK 11e | ERK , GSK-3 , FLT , CDK , Aurora Kinase |
VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent. | |||
T82443 | ERK-CLIPTAC | PROTACs | |
ERK-CLIPTAC is a PROTAC (PROteolysis TArgeting Chimera) molecule designed to induce the degradation of Extracellular signal-Regulated Kinase (ERK) [1]. | |||
T74997 | ERK-IN-6 | ||
ERK-IN-6 (compound 6g) serves as a potent anti-proliferative agent against esophageal squamous cell carcinoma (ESCC), inducing apoptosis through the ERK pathway. This compound has potential applications in ESCC research ... | |||
T71316 | ERK Inhibitor II (Negative control) | ||
ERK Inhibitor II (Negative control) effectively blocks extracellular signal-regulated kinase (ERK) and interferes with insulin receptor activation, serving as a useful tool in diabetes research. | |||
T72517 | ERK-IN-2 free base | ||
ERK-IN-2 free base, an inhibitor of ERK2, demonstrates potent efficacy with an IC50 value of 1.8 nM. However, doses exceeding 10 μM may result in off-target toxicity and/or activity. | |||
T5184 | ERK5-IN-1 | ERK | |
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM). | |||
T5535 | ERK5-IN-2 | ERK | |
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. | |||
T80543 | STE-MEK1(13) | ERK Activation Inhibitor Peptide,Ste-MPKKKPTPIQLNP-NH₂ | ERK |
STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1] [2]. | |||
T6S0655 | Corynoxeine | ERK | |
1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty. | |||
TN2346 | Mogrol | ERK , AMPK , STAT | |
Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling. | |||
T8472 | ERK1/2 inhibitor 2 | ASTX-029,ASTX029 | ERK |
ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity. | |||
T11226 | ERK1/2 inhibitor 1 | ERK | |
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. | |||
T5358 | Longdaysin | ERK , Casein Kinase , CDK | |
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM). | |||
T4091 | Temuterkib | LY3214996 | ERK |
Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. | |||
T3856 | Tenuifoliside A | ERK , Others | |
Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways. |